Recombinant library screening methods

Details Recombinant library screening methods Recombinant library screening methods

1990-05-01

1995-06-27

Hutzell, Paula K.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving virus or bacteriophage

4352523, 435 6, 435 696, 435 71, 435 697, 530412, 5303871, C12N 500, C12N 1513, G01N 3353, C07K 1600

Patent

active

054279089

ABSTRACT:
Nucleotide sequences encoding proteins of interest are isolated from DNA libraries using bacteriophage to link the protein to the sequence which encodes it. DNA libraries are prepared from cells encoding the protein of interest and inserted into or adjacent to a coat protein of a bacteriophage vector, or into a sequence encoding a protein which may be linked by means of a ligand to a phage coat protein. By employing affinity purification techniques the phage particles containing sequences encoding the desired protein may be selected and the desired nucleotide sequences obtained therefrom. Thus, for example, novel proteins such as monoclonal antibodies may be produced and conventional hybridoma technology avoided.

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