Pyroglutamyl-histidyl-tryptophanyl-seryl-tyrosyl hydrazides

Details Pyroglutamyl-histidyl-tryptophanyl-seryl-tyrosyl hydrazides Pyroglutamyl-histidyl-tryptophanyl-seryl-tyrosyl hydrazides

1972-05-25

1978-12-05

Phillips, Delbert R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125LH, C07C10352

Patent

active

041285409

ABSTRACT:
A new decapeptide having the formula, pGlu-His-Trp-Ser-Tyr-Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2); salts thereof; production thereof by reacting pGlu-His-Trp-Ser-Tyr(N.sub.3) with Gly-Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), by reacting pGlu-His-Trp-Ser-Tyr-Gly(N.sub.3) with Leu-NO.sub.2 Arg-Pro-Gly(NH.sub.2), or by reacting pGlu-His-Trp-Ser-Tyr-Gly-Leu(N.sub.3) with NO.sub.2 Arg-Pro-Gly(NH.sub.2); certain peptide intermediates and their salts used in the production thereof; and the use thereof in the preparation of luteinizing hormone releasing factor.

REFERENCES:
patent: 3778427 (1973-12-01), Flouret
patent: 3780014 (1973-12-01), Flouret
patent: 3781272 (1973-12-01), Flouret
patent: 3784535 (1974-01-01), Flouret
patent: 3787385 (1974-01-01), Folkers et al.
patent: 3787386 (1974-01-01), Flouret et al.
patent: 3790554 (1974-02-01), Flouret
patent: 3790555 (1974-02-01), Flouret et al.
patent: 3796697 (1974-03-01), Flouret
Baba et al., Biochem. Biophys. Res. Comm., 44, 459 (1971).
Matsuo et al., Biochem. Biophys. Res. Comm., 43, 1334 (1971).
Burgus et al., C.R. Acad. Sci. Paris, 273, Ser. D, 1611 (1971).
M. Bodanszky and M. Ondetti, "Peptide Synthesis", Interscience, New York (1966), pp. 75-81.
Merrifield, Adv. in Enzymology, 32, 243-244 (1969).

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