Steroidal-17-spiro-dihydrofuranones

Details Steroidal-17-spiro-dihydrofuranones Steroidal-17-spiro-dihydrofuranones

1980-01-18

1981-01-06

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07J 7100

Patent

active

042435862

ABSTRACT:
Steroidal-17-spiro-dihydrofuranones, i.e., steroid having in the 17-position a group having the partial structural formula ##STR1## wherein R.sub.1 is bromine, chlorine, or fluorine; R.sub.2 is alkyl, aryl, or arylalkyl; R.sub.3 is hydrogen, .alpha.-methyl, .beta.-methyl, hydroxy or a conventional hydrolyzable ester thereof, have topical antiinflammatory activity.

REFERENCES:
patent: 3642780 (1972-02-01), Alvarez
patent: 3644340 (1972-02-01), Berkoz
patent: 3757009 (1973-09-01), Anner
patent: 3945997 (1976-03-01), Cimarusti

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