Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
1999-10-01
2002-03-19
Carlson, Karen Cochrane (Department: 1653)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
57, 57, 57, 57, 57
Reexamination Certificate
active
06358929
ABSTRACT:
The invention relates to a method of cosmetic treatment which makes it possible in particular to prevent or reduce the intolerance reactions of the skin, by virtue of the use of a cosmetic composition comprising a particular peptide as additive.
The use of such a peptide as additive in a cosmetic composition makes it possible to reduce the risks of developing contact dermatitis (also called contact eczema) or other skin reactions resulting from a contact hypersensitivity.
It is known that contact hypersensitivity reactions are caused by low-molecular-weight allergens (haptens) which are capable of binding with proteins present in the epidermal cells, including proteins of antigen-presenting cells (Langherans's cells), to form protein-hapten complexes (or conjugates). The antigen-presenting cells of the epidermis then migrate and sensitize T lymphocytes. After a latent period which is about 4 to 5 days, when the site of epidermis again comes into contact with the allergen (triggering reaction), the sensitized T cells migrate to this site and induce the release of cytokines which cause the arrival of macrophages and of nonsensitized T cells which are in turn activated. This influx of cells may result in particular in the formation of an oedema or of vesicles which generally occurs after a few hours or even 1 or 2 days after the triggering reaction in people already sensitized.
Unlike the other allergic reactions, caused by excessive production of immunoglobulins IgE, contact hypersensitivity reactions are mainly linked to a cellular immunological response. Contact hypersensitivity is linked by immunologists to type IV delayed hypersensitivity, also called cell-mediated hypersensitivity.
The sensitizing substances may be very diverse. They are in particular metals or metal salts (chromium, nickel, cobalt, mercury), formalin, synthetic resins (epoxy resins, acrylic and phenolic resins), latexes, medicaments for local application, some cosmetics, dyes or dye precursors (para-phenylenediamine, aniline, aminophencls), pesticides, some synthetic tissues, some plant products (in particular pentadecylcatechols or “poison ivy”), or preservatives.
Thus, many substances are capable of causing contact dermatitis, both in professional life and In daily life.
Contact hypersensitivity. which manifests itself in particular by an irritation, can, in the acute forms, cause an erythema, an oedema, the formation of vesicles, or a pruritus or a burning sensation.
The most serious forms of contact dermatitis require a pharmaceutical treatment with cortico-steroids. The latter are therefore used after a triggering of the hypersensitivity reaction. Their a posteriori therapeutic use, although effective, is therefore curative and not preventive. In addition, their mode of action can cause, in the long term, undesirable effects (in particular lightening of the skin, atrophy of the skin and risk of skin superinfection).
Moreover, it is known that a lot of molecules, of great diversity, are capable of being used as constituents of cosmetic compositions. It is also known that an increase is currently observed in the number of cases of cross-contact hypersensitivity reactions. Thus, the application of cosmetic compositions risks causing such reactions in the users.
It is therefore desirable to be able to have available new agents which make it possible to prevent contact hypersensitivity reactions and to reduce the risks of occurrence of such a reaction in humans, and in particular in people having hypersensitive skins, also called intolerant and/or reactive skins.
The present invention is based on the discovery of the properties of some peptides capable of preventing contact hypersensitivity reactions and of reducing the risks of occurrence of such a reaction. Such an effect is clearly different from an anti-inflammatory effect, as shown, for example, by the experimental section below.
The invention relates more precisely to the use of particular peptides containing the peptide sequence Lysine-Proline-Valine as additives in a cosmetic composition or as active ingredients in the preparation of a medicament intended to suppress or reduce contact hypersensitivity reactions, with the exception of the use of melanotropin. Melanotropin, also called &agr;-MSH, is a known natural peptide having 13 amino acid residues (all of L configuration) and containing, at positions 11 to 13, the peptide sequence indicated.
An activity of modulator of the response to contact hypersensitivity has been described for melano-tropin by RUEINS et al., J. Invest. Dermatol. 93, 511-517 (1989).
Each of the amino acid residues of the peptides used according to the present invention may be of any configuration, L or D.
The subject of the invention is therefore a method of cosmetic treatment, characterized in that, with the aim of preventing or reducing the intolerance reactions of the skin linked to a contact hypersensitivity, a customary cosmetic composition containing, as additive, at least one peptide containing the peptide sequence Lysine-Proline-Valine, with the exception of melano-tropin, or a derivative of such a peptide, is applied to the skin or the superficial body growths.
“Superficial body growths” are understood to mean the hair, the nails and the body hair (in particular eyelashes and eyebrows).
The method of cosmetic treatment of the invention is intended for particular for people having hypersensitive or intolerant skin.
The subject of the invention is also the use, as active ingredient, in the preparation of a medicament intended for combating (preventatively or curatively) contact hypersensitivity reactions, of at least one peptide (or of a derivative of such a peptide) containing the peptide sequence Lysine-Proline-Valine, as defined above, with the exception of the use of melanotropin.
The peptide used according to the invention may contain in particular from 3 to 10 amino acid residues, and in particular 3, 4, 5 or 6 amino acid residues, which may each be, independently, of L or D configuration.
By way of example, at least one amino acid residue of the peptide, in particular at least one amino acid residue of the peptide sequence Lysine-Proline-Valine, and in particular the proline residue, may have the D configuration. The invention includes the use of peptides as defined above, in which the amino acid residues constituting the peptide sequence Lysine-Proline-Valine all have the D configuration. The peptides used according to the invention are in particular those in which, in addition, at least part (including all) of the amino acid residues other than those of the sequence Lys-Pro-Val have the D configuration.
The invention relates in particular to the use of peptides containing at least the peptide sequence of formula I:
Lys-Pro-Val (I)
as well as the use of derivatives of these peptides, with the exception of the use of melanotropin. The derivatives of the peptides containing the sequence of formula I are for example those in which at least one functional group (in particular the amine and carboxyl groups), is protected with a protecting group. Of course, the protecting group should be compatible with a use in the cosmetics or pharmaceutical field. The customary protecting groups are well known. The peptide derivatives comprise in particular those for which the terminal carboxyl group and the other carboxyl groups which may be present are in the form of an ester (for example lower alkyl ester) or of an amide, and/or those for which the N-terminal amine group and the other amine groups which may be present are in acylated (for example acetylated) form. More generally, the derivatives of the peptides containing the peptide sequence of formula I include not only the addition salts with carboxylic organic acids, and not only the acetates, but also other addition salts such as for example the trifluoroacetates, as well as the addition salts with inorganic acids such as the sulphates, hydrochlorides and the like. The derivatives also include the salts resulting from the salivation of the carboxyl group
Duranton Albert
Mahe Yann F.
Carlson Karen Cochrane
L'Oreal
Oliff & Berridg,e PLC
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