Pyrido-pyrimidine compounds as medicaments

Details Pyrido-pyrimidine compounds as medicaments Pyrido-pyrimidine compounds as medicaments

2008-03-18

2008-03-18

Rao, Deepak (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C544S279000

Reexamination Certificate

active

07345045

ABSTRACT:
The invention is directed to methods to inhibit TGF-β and/or p38-α kinase using compounds of the formulaor the pharmaceutically acceptable salts thereofwherein R3is a noninterfering substituent;each Z is CR2or N, wherein no more than two Z positions in ring A are N, and wherein two adjacent Z positions in ring A cannot be N;each R2is independently a noninterfering substituent;L is a linker;n is 0 or 1; andAr′ is the residue of a cyclic aliphatic, cyclic heteroaliphatic, aromatic or heteroaromatic moiety optionally substituted with 1-3 noninterfering substituents.

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