Human T2R61 taste receptor and related assays for...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C435S007210, C436S501000

Reexamination Certificate

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07399601

ABSTRACT:
The claimed invention relates to the discovery of a specific human taste receptor in the T2R taste receptor family, hT2R61 that responds to particular bitter compounds The present invention further relates to the use of this receptor in assays for identifying ligands that modulate the activation of this taste receptor. These compounds may be used as additives and/or removed from foods, beverages and medicinals in order to modify (block) T2R-associated bitter taste. A preferred embodiment is the use of the identified compounds as additives in foods, beverages and medicinals for blocking bitter taste.

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Chandrashekar et al., Cell 100(703-711)2000.
Alexander et al., Proc. Natl. Acad. Sci. 89(3352-3356)1992.
Bowie et al., 1990, Science 247:1306-1310.
Guo-HH et al. PNAS 101(25)9205-9210, 2004.

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