Methods of treating cerebral ischemia

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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C514S014800, C514S415000, C514S419000

Reexamination Certificate

active

07319090

ABSTRACT:
The present invention provides methods of treating cerebral ischemia in mammals comprising inducing hypothermia in a mammal before, during, or following cerebral ischemia in the mammal. The hypothermia is induced by administering to the mammal an effective dose of a neurotensin analog that is capable of crossing the blood-brain barrier and that comprises neo-tryptophan.

REFERENCES:
patent: 6214790 (2001-04-01), Richelson et al.
patent: 6231594 (2001-05-01), Dae
patent: 6572638 (2003-06-01), Dae et al.
patent: 6582457 (2003-06-01), Dae et al.
patent: 2004/0014651 (2004-01-01), Richelson et al.
“Nuerotensin-Induced Hypothemia Prevents Hipocampal Neuronal Damage and Increased Locomotor Activity Ischemic Gerbilis”, Babcock et al., Brain Research Bulletin, 1993, 32(4), 373-8.
“Animal Models of Focal and Global Cerebal Ischemia”, Traystman, R., ILAR Journal, vol. 44, No. 2, 2003.
“Therapeutic Hypothermia for Severe Traumatic Brain Injury”, Kochanek et al., JAMA, Jun. 11, 2003, vol. 289, No. 22, Reprint.
Katz, Laurence, et al., “Neurotensin Analog NT69L Induces Rapid and Prolonged Hypothermia after Hypoxic Ischemia”, Academic Emergency Medicine vol. 8, No. 12: 1115-1121, Dec. 2001.
Katz, Laurence, et al., “Neurotensin Analog Induces Rapid and Prolonged Hypothermia after Cerebral Ischemia”, Academic Emergency Medicine vol. 7, No. 5: 425, 2000.
Griffith, B.D., et al., “Induction of Brain Hypothemia by a Neurotensin Analog in Awake Rats”, displayed at the 25thInternational Stroke Conference—New Orleans, LA, American Heart Association, Feb. 10-12, 2000.
Banks, William, et al., “Permeability of the blood-brain barrier to the nuerotensin8-13analog NT1”, Brain Research vol. 695: 59-63, 1995.
Benmoussa, M., et al., “Low Doses of Neurotensin in the Preoptic Area Produce Hyperthermia. Comparison With Other Brain Sites and With Neurotensin-Induced Analgesia”, Brian Research Bulletin vol. 39, No. 5: 275-279, 1996.
Bernard, S. et al., “Treatment of Comatose Survivors of Out-of-Hospital Cardiac with Induced Hypothermia”, New Engl. J. Med. vol. 349, No. 8: 557-563, Feb. 21, 2002.
Bleyaert, A., et al., “Effect of postcirculatory-arrest life-support on neurological recovery in monkeys”, Critical Care Medicine vol. 8, No. 3: 153-156, 1980.
Clifton, G., et al., “Lack of Effect of Induction of Hypothermia after Acute Brain Injury”, The New England J. Med. vol. 344, No. 8: 556-563, Feb. 22, 2001.
Coimbra, C., et al., “Moderate hypothermia mitigates neuronal damage in the rat brain when initiated several hours following transient cerebral ischemia”, Acta Neuropathologica vol. 87, No. 4: 325-331, 1994.
Colbourne, F., et al., “Delayed Postischemic Hypothermia: a Six Month Survial Study Using Behavioral and Histological Assessments of Neuroprotection”, The Journal of Neuroscience vol. 15, No. 11: 7250-7260, 1995.
Colbourne, F., et al., “Postischemic Hypothermia. A Critical Appraisal with Implications for Clinical Treatment”, Molecular Neurobiology vol. 14, 171-201, 1997.
Cusack, Bernadette, et al., “Effects of a novel neurotensin peptide analog given extacranially on CNS behaviors mediated by apomorphine and haloperidol”, Brain Research vol. 856: 48-54, 2000.
Globus, M., et al., “Excitoxic index—a biochemical marker of selective vulnerability”, Neuroscience Letters vol. 127: 39-42, 1991.
Gordon, C.J., “A review of terms and proposed nomenclature for regulated vs. forced, neurochemical-induced changes in body temperature”, Life Sciences vol. 32: 1285-1295, 1983.
Gordon, C.J. et al., “Dynamics of behaviroal thermoregulation in the rat”, Amer. J. Physiol. 261: R705-R711, 1991.
Gordon, C.J., The role of behaviroal thermoregulation as a thermoeffector during prolonged hypoxla in the rat, J. Thermal Biol. vol. 22: 315-324, 1997.
Gordon, C.J., “The therapeutic potential of regulated hypothermia”, Emergency Medicine Journal, vol. 18: 81-89, 2001.
Gordon, C.J., “24-hour control of body temperature in rats: I. Integration of behavioral and autonomic effectors”, Amer. J. Physiol. vol. 261: R71-R77, 1994.
Gunn, A., et al., “Selective Head Cooling in New Born Infants after Perinatal Asphyxia: a Safety Study”, Pediatrics vol. 102, No. 4: 885-892, Oct. 1998.
Gunn, A., et al., “Should We Try to Prevent Hypothermia after Cardiac Arrest?”, Pediatrics vol. 106, No. 1: 132-133 Jul. 2000.
Handler, C.M., et al., “Interaction betw en Opioid Agonists and Neurotensin on Thermoregulation in the Rat. I. Body Temperature”, J. Pharmacology and Exp. Ther. vol. 274, No. 1: 284-292, 1995.
Hickey, R., et al., “Delayed, spontaneous hypothermia reduces neuronal damage after asphyxial cardiac arrest in rats”, Critical Care Medicine vol. 28, No. 10: 3511-3516, Oct. 2000.
Hickey, R., et al., “Use of Morris Water Maze and Acoustic Startle Chamber to Evaluate Neurologic Injury after Asphyxial Arrest in Rats”, Pediatric Research vol. 39, No. 1: 77-84, 1996.
Hochachka, P.W., “Defense Strategies Against Hypoxia and Hypothermia”, Science vol. 231: 234-241, Jan. 17, 1986.
Kammersgaard, L.P., et al., “Feasibility and Safety of Inducing Modest Hypothermia in Awake Patients with Acute Stroke Through Surface Cooling: A Case-Control Study”, Stroke: 2251-2256, Sep. 2000.
Katz, Laurence, et al., “Outcome Model of Asphyxial Cardiac Arrest in Rats”, Journal of Cerebral Blood Flow and Metabolism vol. 15, No. 6: 1032-1039, 1995.
Kraig R., et al., “Hydrogen Ions Kill Brain at Concentrations Reached in Ischemia”, Journal of Cerebral Blood Flow and Metabolism vol. 7, No. 4: 379-386, 1987.
Kuboyama, K., et al., “Delaying cooling negates the beneficial effect of mild resuscitative cerebral hypothermia after cardiac arrest in dogs: A prospective, randomized study”, Critical Care Medicine vol. 21, No. 9: 1348-1358, 1993.
Marion, D., et al., “Resuscitative hypothermia”, Critical Care Medicine vol. 24, No. 2 (Suppl.): S81-S89, 1996.
Marion, D., et al., “Treatment of Traumatic Brain Injury with Moderate Hypothermia”, The New England Journal of Medicine vol. 336, No. 8: 540-546, Feb. 20, 1997.
Morris, G.M., et al., “Place navigation impaired in rats with hippocampal lesions”, Nature vol. 297: 681-685, Jun. 1982.
Muchlinski, et al, “The Concentrations for Four Neuropeptides in Various Brain Areas of Summer Active and HibernatingSpermophilus Lateralis”, Comp. Biochem. Physiol. C. Toxicol. Pharmacol. vol. 74: 185-189, 1982.
Negovsky, Vladimir, “Postresuscitation disease”, Critical Care Medicine vol. 16, No. 10: 942-946, Oct. 1988.
Prange, A.J., Jr., et al., “Neurotensin: Distribution of Hypothermic Response in Mammalian and Submammalian Vertebrates”, Pharmacol. Biochem. Behav. vol. 11: 473-477, 1979.
Pulsinelli, William, et al., “Temporal Profile of Neuronal Damage in a Model of Transient Forebrain Ischemia”, Annals of Neurology vol. 11, No. 5: 491-498, May 1982.
Sallmen, Tina, et al., “Major Changes in the Brain Histamine System of the Ground SquirrelCitellus lateralisduring Hibernation”, The Journal of Neuroscience vol. 19, No. 5: 1824-1835, Mar. 1, 1999.
Smith, Charles, et al., “Preventing Hypothermia: Convective and Intravenous Fluid WarmingVersusConvective Warming Alone”, J. Clin. Anesth., vol. 10: 380-385, Aug. 1998.
Tagami, M., et al., “Insulin-Like Growth Factor-1 Attenuates Apoptosis in Hippocampal Neurons Caused by Cerebral Ischemia and Reperfusion in Stroke-Prone Spontaneously Hypertensive Rats”, Laboratory Investigation vol. 76, No. 5: 613-617, May 1997.
The Hypothermia After Cardiac Arrest Study Group, “Mild Therapeutic Hypothermia to Improve the Neurologic Outcome After Cardiac Arrest”

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