Surgery – Diagnostic testing – Detecting nuclear – electromagnetic – or ultrasonic radiation
Reexamination Certificate
2008-05-06
2008-05-06
Casler, Brian L. (Department: 3737)
Surgery
Diagnostic testing
Detecting nuclear, electromagnetic, or ultrasonic radiation
C600S437000, C600S438000, C600S439000, C600S473000, C600S476000, C601S002000
Reexamination Certificate
active
07367948
ABSTRACT:
An acoustic monitoring method and system in laser-induced optical breakdown (LIOB) provides information which characterize material which is broken down, microbubbles in the material, and/or the microenvironment of the microbubbles. In one embodiment of the invention, femtosecond laser pulses are focused just inside the surface of a volume of aqueous solution which may include dendrimer nanocomposite (DNC) particles. A tightly focused, high frequency, single-element ultrasonic transducer is positioned such that its focus coincides axially and laterally with this laser focus. When optical breakdown occurs, a microbubble forms and a shock or pressure wave is emitted (i.e., acoustic emission). In addition to this acoustic signal, the microbubble may be actively probed with pulse-echo measurements from the same transducer. After the microbubble forms, received pulse-echo signals have an extra pulse, describing the microbubble location and providing a measure of axial microbubble size. Wavefield plots of successive recordings illustrate the generation, growth, and collapse of microbubbles due to optical breakdown. These same plots can also be used to quantify LIOB thresholds.
REFERENCES:
patent: 5615675 (1997-04-01), O'Donnell et al.
patent: 5732046 (1998-03-01), O'Donnell et al.
patent: 5749364 (1998-05-01), Sliwa et al.
patent: 5810731 (1998-09-01), Sarvazyan et al.
patent: 6165440 (2000-12-01), Esenaliev
patent: 6471968 (2002-10-01), Baker et al.
patent: 6546272 (2003-04-01), MacKinnon et al.
Milas, Susanne M., et al., Acoustic Characterization of Microbubble Dynamics In Laser-Induced Optical Breakdown, IEEE Transactions on Ultrasonics, Ferroelectrics And Frequency Control, vol. 50, No. 5, May 2003, pp. 517-522.
Milas, Susanne M., et al., Acoustic Detection of Microbubble Formation Induced By Enhanced Optical Breakdown of Silver/Dendrimer Nanocomposites, Applied Physics Letters, vol. 82, No. 6, Feb. 10, 2003, pp. 994-996.
O'Donnell, M., et al., Acoustic Detection of Laser Induced Optical Breakdown In Dendrimer Nanocomposites: Implications For Site Targeted Molecular Diagnostics An Therapeutics, IEEE Ultrasonic Symposium, Oct. 8-11, 2002, pp. 1961-1964.
Tomita, Y. et al., Behavior of Laser-Induced Caitation Bubbles in Liquid Nitrogen, Journal of Applied Physics; vol. 88, No. 10, Nov. 15, 2000, pp. 5993-6001.
Venugopalan, Vasan, et al., Role of Laser-Induced Plasma Formation n Pulsed Cellular Microsurgery and Micromanipulation, Physical Review Letter, vol. 88, No. 7, Feb. 18, 2002, pp. 078103-1-078103-4.
Noack, Joachim, et al., Influence of Pulse Duration on Mechanical Effects After Laser-Induced Breakdown in Water, Journal of Applied Physics, vol. 83, No. 12, Jun. 15, 1998, pp. 7488-7495.
Ye, Jing Yong, et al., Enhancement of Laser-Induced Optical Breakdown Using Metal/Dendrimer Nanocomposites, Applied Physics Letters, vol. 80, No. 10, Mar. 11, 2002, pp. 1713-1715.
Dayton, Paul A., et al., Optical An acoustical Dynamics of Microbubble Contrast Agents Inside Neutrophils, Biophysical Journal, vol. 80, Mar. 2001, pp. 1547-1556.
Baker, Jr. James R.
Balogh Lajos P.
Emelianov Stanislav Y.
Hollman Kyle W.
Milas Susanne M.
Brooks & Kushman P.C.
Casler Brian L.
Kish James
The Regents of the University of Michigan
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