Mouse titers after two immunizations with VLPs alone

Chemistry: molecular biology and microbiology – Vector – per se

Reexamination Certificate

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C424S199100

Reexamination Certificate

active

07371572

ABSTRACT:
The invention described herein relates to compositions and methods for stimulating immune responses in vivo against a tolerogen. Novel biotechnological tools, pharmaceuticals, therapeutics and prophylactics, which concern chimeric or conjugated virus-like particles, and methods of use of the foregoing are provided for the study of B cell tolerance and the treatment or prevention of human diseases, which involve the onset of B cell tolerance, such as chronic viral infection, chronic inflammatory disease, and neoplasia.

REFERENCES:
patent: 5143726 (1992-09-01), Thornton et al.
patent: 5437951 (1995-08-01), Lowy et al.
patent: 5618536 (1997-04-01), Lowy et al.
patent: 5698424 (1997-12-01), Mastico et al.
patent: 5723287 (1998-03-01), Russell et al.
patent: 6719978 (2004-04-01), Schiller et al.
patent: 684782 (1994-12-01), None
patent: 0 385 610 (1994-03-01), None
patent: 752886 (1998-01-01), None
patent: WO 9929723 (1999-06-01), None
patent: WO 0032227 (2000-06-01), None
Backer et al. Micro. Mole. Biol. Rev. 1999, vol. 63, No. 4, pp. 862-922.
Zeng et al. J. Virol. 1998, vol. 72, No. 1, pp. 201-208.
Neiland et al. J. Cell. Biochem. May 1999, vol. 73, pp. 145-152.
Kirnbauer et al. Proc. Natl. Acad. Sci. U.S.A. 1992, vol.89, pp. 12180-12184.
Baker et al. Biophys J. Dec. 1991;60 (6):1445-1456.
Baker et al. Micro. Mole. Biol. Retro. 1999, vol. 63, No. 4, pp. 862-922.
Olson et al. (J. Virol. 1999, vol. 73, No. 5, pp. 4145-4155.
Altin et al. Analytical Biochemistry 1995, vol. 224, pp. 382-389.
Vasiljeva, I., et al. (1998) “Mosaic Qβ Coats as a New Presentation Model.”FEBS Lett.431:7-11.
Adams, S.E. (1993) “Induction of humoral and cellular immunity by recombinant, particulate antigen presentation systems,” Database Embase, Accession No. EMB-1994076722, XP002367358.
Chang. C. et al. (1994) “Phenotypic mixing between different hepadnavirus nucleocapsid proteins reveals C protein dimerization to becispreferential.”Journal of Virology, 68:5225-5231.
Aichele, P., et al. (1994) peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model.PNAS USA91:444-448.
Albert, L.J., et al. (1999) Molecular Mimicry and Autoimmunity.N Engl. J. Med.341:2068-2074.
Alkhatib, G., et al. (1996) CC CKR5: A Rantes, MIP-1α, MIP-1β Receptor as a Fusion Cofactor for Macrophage-Tropic HIV-1.Science272:1955-1958.
Alkhatib, G., et al. (1997) CC Chemokine Receptor 5-Mediated Signaling and HIV-1 Co-receptor Activity Share Common Structural Determinants.J. Biol. Chem.272:19771-19776.
Atchinson, R.E., et al. (1996) Multiple Extracellular Elements of CCR5 and HIV-1 Entry: Dissociation from Response to Chemokines.Science274:1924-1926.
Bachmann, M.F., et al. (1993) The Influence of Antigen Organization on B Cell Responsiveness.Science262:1448-1451.
Bachmann, M.F., et al. (1996) The influence of virus structure on antibody responses and virus serotype formation.Immunol. Today17:553-558.
Bachmann, M.F., et al. (1997) Neutralizing Antiviral B Cell Responses.Annu. Rev. Immunol.15:235-270.
Bachmann, M.F., et al. (1997) The Role of Antibody Concentration and Avidity in Antiviral Protection.Science276:2024-2027.
Baker, T.S., et al. (1991) Structures of bovine and human papillomaviruses Analysis by cryoelectron microscopy and three-dimensional image reconstruction.Biophys. J.60:1445-1456.
Baselga, J., et al. (1996) Phase II Study of Weekly Intravenous Recombinant Humanized Anti-p185HER2Monoclonal Antibody in Patients with HER2
eu-Overexpressing Metastatic Breast Cancer.J. Clin. Oncol.14:737-744.
Bloom, J.W., et al. (1993) Epitope Mapping and Functional Analysis of Three Murine lgG1 Monoclonal Antibodies to Human Tumor Necrosis Factor-α.J. Immunol.151:2707-2716.
Booy, F.P., et al. (1998) Two Antibodies that Neutralize Papillomavirus by Different Mechanisms Show Distinct Binding Patterns at 13 Å Resolution.J. Mol. Biol.281:95-106.
Boring, L., et al. (1996) Molecular Cloning and Functional Expression of Murine JE (Monocyte Chemoattractant Protein 1) and Murine Macrophage Inflammatory Protein 1α Receptors.J. Biol. Chem.271:7551-7558.
Chackerian, B., et al. (1999) Induction of autoantibodies to mouse CCR5 with recombinant papillomavirus particles.PNAS USA96:2373-2378.
Chackerian, B., et al. (2001) Conjugation of a self-antigen to papillomavirus-like particles allows for efficient induction of protective autoantibodies,J. Clin. Invest.108:415-423.
Chang, T.W. (2000) The pharmacological basis of anti-IgE therapy.Nat. Biotechnol.18:157-162.
Choe, H., et al. (1996) The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates.Cell85:1135-1148.
Chu, R.S., et al. (1997) CpG Oligodeoxynucleotides Act as Adjuvants that Switch on T Helper 1 (Th1) Immunity.J. Exp. Med.186:1623-1631.
Ciapponi, L., et al. (1997) Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist.Nat. Biotechnol.13:997-1001.
Conry, R. M., et al. (Mar. 1995) Breaking tolerance to carcinoembryonic antigen with a recombinant vaccinia virus vaccine in man.Proceedings of the American Association for Cancer Research.36:492 (Abstract 2930).
Dalum, I., et al. (1996) Breaking of B Cell Tolerance Toward a Highly Conserved self ProteinJ. Immunol.157:4796-4804.
Dalum, I., et al. (1997) Induction of Cross-reactive Antibodies Against a Self Protein by Immunization with a Modified Self Protein Containing a Foreign T Helper Epitope.Mol. Immunol.34:1113-1120.
Dalum, I., et al. (1999) Therapeutic antibodies elicited by immunization against TNF-αNat. Biotechnol.17:666-669.
Deng, H., et al. (1996) Identification of a major co-receptor for primary isolates of HIV-1.Nature381:661-666.
Doranz, B.J., et al. (1996) A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors.Cell85:1149-1158.
Dragic, T., et al. (1996) HIV-1 entry into CD4+cells is mediated by the chemokine receptor CC-CKR-5.Nature381:667-673.
Eck, M.J., et al. (1989) The Structure of Tumor Necrosis Factor-+ at 2.6 Å Resolution. J. Biol. Chem. 264:17595-17605.
Eigler, A., et al. (1997) Taming TNF: strategies to restrain this proinflammatory cytokine.Immunol. Today18:487-492.
Fehr, T., et al. (1997) Role of Repetitive Antigen Patterns for Induction of Antibodies Against Antibodies,J. Exp. Med.185:1785-1792.
Fitchen, J., et al. (1995) Plant virus expressing hybrid coat protein with added murine epitope elicits autoantibody response.Vaccine13:1051-1057.
Green, N.M. (1965) A Spectrophotmetric Assay for Avidin and Biotin Based on Binding of Dyes by Avidin.Biochem. J.94:23c-24c.
Greenstone, H.L., et al. (1998) Chimeric papillomavirus virus-like particles elicit antitumor immunity against the E7 oncoprotein in an HPV16 tumor model.PNAS USA95:1800-1805.
Han, S., et al. (1997) V(D)J Recombinase Activity in a Subset of Germinal Center B Lymphocytes.Science278:301-305.
Harro, C.D., et al. (2001) Safety and Immunogenicity Trial in Adult Volunteers of a Human Papillomavirus 16 L1 Virus-Like Particle Vaccine.J. Natl. Cancer Inst.93:284-292.
Hedman, K., et al. (1988) Recent Rubella Virus Infection Indicated by a Low Avidity of Specific IgG.J. Clin. Immunol.8:214-221.
Herkel, J., et al. (1997) Humoral Mechanisms in T cell Vaccination: Induction and Functional Characterization of Anti-lymphocytic Autoantibodies.J. Autoimmunity10:137-146.
Hertz, M., et al. (1998) Receptor editing and commitment in B lymphocytes.Curr. Opin. Immunol.10:208-213.
Hertz, M., et al. (1998) V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling.Nature394:292-295.
Ho. S.N., et al. (1989) Site-directed mutagenesis by overlap extension using the polymerase chain reaction,Gene77, 51-59.
Karlsen, A.E. and Dyrberg, T. (1998) Molecular mimicry between non-self, modified self and self in autoimmunity.Semin. Immunol.10:25-34.
Kim, S.K., et al. (2001) Effect of immunological adjuvant combinations on the antibody and T-cell response to vaccination with MUC1-KLH and GD3

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