Statine derivatives for the treatment of Alzheimer's disease

Details Statine derivatives for the treatment of Alzheimer's disease Statine derivatives for the treatment of Alzheimer's disease

2008-04-15

2008-04-15

Davis, Zinna N. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S270000, C514S617000, C546S328000, C548S190000, C564S152000, C564S153000

Reexamination Certificate

active

07358264

ABSTRACT:
The present invention relates to compounds of formula (I):useful in treating Alzheimer's disease and other similar diseases. These compounds include inhibitors of the beta-secretase enzyme that are useful in the treatment of Alzheimer's disease and other diseases characterized by deposition of A beta peptide in a mammal. The compounds of the invention are useful in pharmaceutical compositions and methods of treatment to reduce A beta peptide formation.

REFERENCES:
patent: 5734054 (1998-03-01), Diianniet al.
patent: WO 99/02153 (1999-01-01), None
Dolle et al., “Solid-phase synthesis of alpha-hydroxy phosphonates and hydroxystatine amides. Transition-State isosteres derived from resin-bound amino acid aldehydes”,Tetrahedron Letters, vol. 42, No. 10, Mar. 4, 2001, 1855-1858.
Kroemer et al., “3D-Quantitative Structure-Activity Relationships of Human Immunodeficiency Virus Type-1 Proteinase Inhibitors: Comparative Molecular Field Analysis of 2-Heterosubstituted Statine Derivatives-Implications for the Design of Novel Inhibitors”,Journal of Medicinal Chemistry, vol. 38, No. 25, 1995, 4917-4928.
Langlois, “Short Stereocontrolled Synthesis of (2S, 3S, 4R)-3, 4-Dihydroxyglutamic Acid”,Tetrahedron Letters, vol. 40, No. 50, Dec. 10, 1999, 8801-8803.
Lehr et al., “Inhibitors of Human Immunodeficiency Virus Type 1 Protease Containing 2-Aminobenzyl-Substituted 4-Amino-3-Hydroxy-5-Phenylpentanoic Acid: Synthesis, Activity and Oral Bioavailability”,J. Med. Chem., vol. 39, No. 10, 1996, 2060-2067.
Scholz et al., “Inhibitors of HIV-1 Proteinase Containing 2-Heterosubstituted 40Amino-3-Hydroxy-5-Phenylpentanoic Acid: Synthesis, Enzyme Inhibition, and Antiviral Activity”,Journal of Medicinal Chemistry, vol. 37, No. 19, 1994, 3079-3089.

Affiliated with

Also associated with

Rating

Statine derivatives for the treatment of Alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Statine derivatives for the treatment of Alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Statine derivatives for the treatment of Alzheimer's disease will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2797055