Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...
Patent
1979-11-29
1981-10-27
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Bacterium or component thereof or substance produced by said...
544 22, 544 27, A61K 31545
Patent
active
042973520
ABSTRACT:
Novel syn isomers of 3-substituted-7-amino-thiazolyl-acetamido-cephalosporanic acid compounds of the formula ##STR1## wherein R is selected from the group consisting of alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 5 carbon atoms and --CH.sub.2 --S--R.sub.1, R.sub.1 is selected from the group consisting of 2-methyl-1,3,4-thiadiazolyl, 1-methyl tetrazolyl, acyl of an organic carboxylic acid of 2 to 4 carbon atoms and ##STR2## R.sub.2 is selected from the group consisting of alkyl and alkoxy of 1 to 4 carbon atoms and A is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, magnesium and a non-toxic, pharmaceutically acceptable organic amine having antibiotic activity and novel intermediates and process for their preparation.
REFERENCES:
patent: 4008246 (1977-02-01), Ochiai et al.
patent: 4024134 (1977-05-01), Gregson et al.
patent: 4098888 (1978-07-01), Ochiai et al.
Numata et al., Chem. Pharm. Bull., 25(11) 3117-3119 (1977).
Heymes Rene
Lutz Andre
Coughlan, Jr. Paul M.
Roussel Uclaf
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