Process for preparing benzhydrylthioacetamide

Details Process for preparing benzhydrylthioacetamide Process for preparing benzhydrylthioacetamide

2008-03-18

2008-03-18

Zucker, Paul A. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C568S036000

Reexamination Certificate

active

07345188

ABSTRACT:
The present invention is directed to an improved process for preparing modafinil wherein benzhydrylthioacetate is prepared in high yield and purity by the reaction of a haloacetate with the reaction product of thiourea and benzhydrol. The reaction employing the haloacetate is conducted in a solvent comprising an organic solvent such as methanol having dissolved therein an organic base or an inorganic basic salt such as sodium bicarbonate. The resulting benzhydrylthioacetate can be amidated and then oxidized to provide the pharmaceutical grade modafinil in high yield and purity.

REFERENCES:
patent: 4177290 (1979-12-01), Lafon

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