Inhibitors of 15-lipoxygenase

Details Inhibitors of 15-lipoxygenase Inhibitors of 15-lipoxygenase

2008-04-01

2008-04-01

Anderson, Rebecca (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C549S030000

Reexamination Certificate

active

07351727

ABSTRACT:
The present invention provides oxazolyl and thiazolyl inhibitors of 15-LO, pharmaceutical compositions containing such inhibitors and methods for treating diseases related to the 15-LO cascade using such compounds and compositions.

REFERENCES:
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Kelavkar, U. et al., “The Effect of 15-Lipoxygenase -1 Expression on Cancer Cells”, Current Urology Reports, vol. 3, pp. 207-214, 2002.
Setty, B.N., et al., 15-Hydroxyeicosatetraenoic Acid-Medicated Potentiation of Thrombia-Induced Platelet Functions Occurs Via Enhanced Production of Phosphoinositide-Derived Second Messengers—sn-1,2-Diacylglycerol and Inositol-1,4,5-Trisphosphate, Blood., vol. 80, No. 11, pp.
Sultana, S., et al., “Lipoxygenase Metabolites Induced Expression of Adhesion Molecules and Transendothelial Migration of Monocyte-Like HL-60 Cells Is Linked to Protein Kinase C Activation”, Journal of Cellular Physiology, vol. 167, pp. 477-487, 1996.
Tisdale, M.J., “Protein Loss in Cancer Cachexia”, Science's Compass, vol. 289, pp. 2293-2294. 2000.

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