Solid preparation comprising...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C544S309000

Reexamination Certificate

active

07994183

ABSTRACT:
The present invention provides a solid preparation containing 2[[6-[(3R)-3-amino-1 -piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile (compound (A)) or a salt thereof as a pharmaceutically active ingredient. Specifically, the present invention provides a solid preparation containing a granule composed of compound (A) or a salt thereof and an additive (excluding microcrystalline cellulose) and a tablet containing (a) a granule containing compound (A) or a salt thereof and microcrystalline cellulose, and (b) a tableting aid containing magnesium stearate and microcrystalline cellulose.

REFERENCES:
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patent: 5855914 (1999-01-01), Koyama et al.
patent: 2005/0215573 (2005-09-01), Schilling et al.
patent: 2005/0261271 (2005-11-01), Feng et al.
patent: 2007/0060530 (2007-03-01), Christopher et al.
patent: 2008/0275072 (2008-11-01), Ogawa
patent: 2008/0287476 (2008-11-01), Christopher et al.
patent: WO 2005/067976 (2005-07-01), None
patent: WO 2007/033350 (2007-03-01), None
patent: WO 2008/067465 (2008-06-01), None
patent: WO 2008/093878 (2008-08-01), None
patent: WO 2009/022009 (2009-02-01), None
Communication issued Feb. 1, 2010, in corresponding EP 08 722 406.9, 6 pages.
International Search Report dated Oct. 17, 2008 in prior PCT/JP2008/055016, 4 pages.

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