Regulation of bcl-2 gene expression

Details Regulation of bcl-2 gene expression Regulation of bcl-2 gene expression

Filed on

2008-01-01

Date issued

2008-01-01

Examiner

Schnizer, Richard (Department: 1635)

Patent Class

Organic compounds -- part of the class 532-570 series

SubClass

Organic compounds

SubSubClass

Carbohydrates or derivatives

Other Related Categories

C514S04400A

Type

Reexamination Certificate

Status

active

Patent number

07314927

Description

ABSTRACT:
The present invention provides novel anticode oligomers and methods of using them for controlling the growth of cancer cells expressing the bcl-2 gene.

REFERENCES:
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patent: 2001-505401 (2001-04-01), None
patent: WO-93/20200 (1993-10-01), None
patent: 94/14980 (1994-07-01), None
Cosstick et al. Nucleic Acids Research 1984, vol. 12, pp. 1791-1810.
S. Kitada et al., “Investigations of antisense oligonucleotides targeted agains bcl-2 RNAs”, Antisense Research and Development, vol. 3, Aug. 1993, pp. 157-169.
E. Uhlmann et al., “Antisense Oligonucleotides: A new therapeutic Principle”, Chemical Reviews, vol. 90, No. 4, Jun. 1, 1990, pp. 543-583.
J. C. Reed, et al., “Antisense-Mediated Inhibition of BCL2 Protooncogene Expression and Leukemic Cell Growth and Survival Comparisons of Phosphodiester and Phosphorothioate Oligodeoxynucleotides”, Cancer Research, vol. 50, No. 20, 1990, pp. 6565-6570.
D. M. Hockenbery. et al. “BCL2 protein is topographically restricted in tissues characterized by apoptotic cells”, Proc. Natl. Acad. Sci. USA, vol. 88, 1991, pp. 6961-6965.
T. Miyashita and J.C. Reed “BCL2 gene transfer increases relative resistance of S49.1 amd WEH17.2 lymphoid cells to cell death and DNA fragmentation induced by glucocorticoids and multiple chemotherapeutic drugs”, Cancer Research, vol. 52, 911, pp. 5407-5411.
B. Calabretta, “Inhibition of Protooncogene Expression and Antisense Ologodeoxynycleotides: Biological and Therapeutic Implications”, Cancer Research, vol. 51, No. 17, Sep. 1, 1991, pp. 4505-4510.
Boeve, et al., 1994. “Inhibition of human interferon-gamma expression by antisense oligodeoxynucleotides”. J. Leukocyte Biol. 55: 169-174.
Seto, et al., 1988. “Alternative promoters and exons, somatic mutation and deregulation of the Bcl-2-lg fusion gene in lymphoma”. The EMBO Journal 7(1): 123-131.

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