Sulpiride pharmaceutical compositions

Details Sulpiride pharmaceutical compositions Sulpiride pharmaceutical compositions

2008-04-15

2008-04-15

Saeed, Kamal A (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S571000

Reexamination Certificate

active

07358271

ABSTRACT:
The present invention relates to pharmaceutical compositions containing sulpiride compounds having the general formula:where R1is branched or straight chain alkyl having from 1 to about 7 carbon atoms, a substituted or unsubstituted aryl, a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted aralkyl, a substituted or unsubstituted alkylcycloalkyl, or a group having the formula (CH2)nR2where R2is a substituted or unsubstituted aryl or a substituted or unsubstituted cycloalkyl, and n is an alkyl group having from 0 to about 6 carbon atoms and pharmaceutically acceptable salts or diluents.

REFERENCES:
patent: 6890942 (2005-05-01), Walker et al.
patent: WO 2004/103278 (2004-12-01), None
Liu et al., Bioorganic &Medicinal Chemistry Letters 13 (2003), 3005-3007.
Liu et al., “Acylsulfonamide-Containing PTP1B Inhibitors Designed to Mimic an Enzyme-Bound Water of Hydration”, Bioorganic & Medicinal Chemistry Letters 13 (2003), pp. 3005-3007.
Baluom et al., “Improved intestinal absorption of sulpiride in rats with synchronized oral delivery systems”, Journal of Controlled Release 70 (2001), pp. 139-147.
Naasani et al., “Improving the Oral Bioavailability of Sulpiride by Sodium Oleate in Rabbits”, J. Pharm. Pharmacol, 1995, 47: pp. 469-473.
Kohri et al., “Improving the Oral Bioavailability of Sulpiride by a Gastric-retained Form in Rabbits”, J. Pharm. Pharmacol, 1996, 48: pp. 371-374.

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