Tetronic acid derivative

Details Tetronic acid derivative Tetronic acid derivative

2008-04-15

2008-04-15

Lankford, Jr., Leon B. (Department: 1651)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C536S007100, C435S117000

Reexamination Certificate

active

07358233

ABSTRACT:
The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel tetronic acid derivative, versipelostatin compound (also known as JL68) shown in formula (I) having the activity of suppressing GRP78 expression was isolated from the metabolite ofStreptomyces versipellisstrain 4083-SVS6. Versipelostatin can be obtained from the culture supernatant by culturing the above-mentionedStreptomyces versipellisstrain 4083-SVS6

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