Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-03-01
2011-03-01
Chandrakumar, Nizal S (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07897775
ABSTRACT:
The invention provides crystalline forms of the novel benzimidazole-carboxamide 5-HT4receptor agonist compound, 4-(4-{[(2-isopropyl-1H-benzoimidazole-4-carbonyl)amino]methyl}-piperidin-1-ylmethyl)piperidine-1-carboxylic acid methyl ester. The invention also provides pharmaceutical compositions comprising the crystalline compound, methods of using the compound to treat diseases associated with 5-HT4receptor activity, and processes useful for preparing crystalline forms of the compound.
REFERENCES:
patent: 6294555 (2001-09-01), Kato et al.
patent: 6696468 (2004-02-01), Kato et al.
patent: 7256294 (2007-08-01), Dalziel et al.
patent: 7622587 (2009-11-01), Dalziel et al.
patent: 2006/0270652 (2006-11-01), McKinnell et al.
patent: 2154605 (2001-04-01), None
patent: 11001472 (1999-01-01), None
patent: 20001122784 (2001-05-01), None
patent: 2004277318 (2004-10-01), None
patent: 2004277319 (2004-10-01), None
patent: 2004277320 (2004-10-01), None
patent: 97/35860 (1997-10-01), None
Harada et al., “Novel N-[1-(1-Substituted 4-Piperidinylmethyl)-4-piperidinyl]benzamides as Potent Colonic Prokinetics Agents”, Bioorganic & Medicinal Chemistry Letters 12, pp. 967-970 (2002).
Lopez-Rodriguez et al., “3-D-QSAR/CoMFA and Recognition Models of Benzimidazole Derivatives at the 5 HT4 Receptor”, Bioorganic & Medicinal Chemistry Letters, 11, pp. 2807-2811 (2001).
Lopez-Rodriguez et al., “Benzimidazole Derivates. Part 1: Synthesis and Structure-Activity Relationships of New Benzimidazole-4-carboxamides and Carboxylates as Potent and Selective 5-HT4 Receptor Antagonists”, Bioorganic & Medicinal Chemistry, 7 , pp. 2271-2281 (1999).
Lopez-Rodriguez et al., “Benzimidazole Derivatives. 3. 3D-QSAR/CoMFA Model and Computational Simulation for the Recognition of 5-HT4 Receptor Antagonists”, J. Med. Chem., 45, pp. 4806-4815 (2002).
Lopez-Rodriguez et al., “Benzimidine derivatives 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists”, Journal of Computer-Aided Molecular Design, 17, pp. 515-524 (2003).
Lopez-Rodriguez et al., “Design and Synthesis of New Benzimidazole-Arylpiperazine Derivatives Acting as Mixed 5-HT1A/5-HT3 Ligands”, Bioorganic & Medicinal Chemistry Letters, 13, pp. 3177-3180 (2003).
Lopez-Rodriguez et al., “Study of the bioactive conformation of novel 5-HT4 receptor ligands: influence of an intramolecular hydrogen bond”, Tetrahedron, 57, pp. 6745-6749 (2001).
Dalziel Sean M.
Phizackerley Kirsten M.
Chandrakumar Nizal S
Hagenah Jeffrey A.
Saxon Roberta P.
Theravance Inc.
LandOfFree
Crystalline form of a benzimidazole-carboxamide medicinal... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Crystalline form of a benzimidazole-carboxamide medicinal..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Crystalline form of a benzimidazole-carboxamide medicinal... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2776804