Polynucleotides encoding promyostatin polypeptides

Details Polynucleotides encoding promyostatin polypeptides Polynucleotides encoding promyostatin polypeptides

2008-07-01

2008-07-01

Allen, Marianne P (Department: 1647)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

C435S069100, C435S252300, C435S254110, C435S320100, C536S023500

Reexamination Certificate

active

07393682

ABSTRACT:
The present invention provides isolated polynucleotides encoding promyostatin polypeptides or a peptide portion thereof, polynucleotides complementary thereto, and oligonucleotides that can specifically hybridize to such polynucleotides. The present invention also provides an isolated polynucleotide encoding a mature myostatin peptide.

REFERENCES:
patent: 5616561 (1997-04-01), Barcellos-Hoff
patent: 5827733 (1998-10-01), Lee et al.
patent: 5885794 (1999-03-01), Mathews et al.
patent: 5994618 (1999-11-01), Lee et al.
patent: 6004937 (1999-12-01), Wood et al.
patent: 6369201 (2002-04-01), Barker et al.
patent: WO 91/08291 (1991-06-01), None
patent: WO 94/21681 (1994-09-01), None
patent: WO 96/01845 (1996-01-01), None
patent: WO 98/33887 (1998-08-01), None
patent: 99/02667 (1999-01-01), None
patent: WO99/06559 (1999-02-01), None
patent: 99/40181 (1999-08-01), None
patent: 99/42573 (1999-08-01), None
patent: WO99/56768 (1999-11-01), None
McPherron et al.: “Regulation of skeletal muscle mass in mice by a new TGF-β superfamily member.” Nature, (May 1, 1997) 387 (6628) 83-90., XP002085797.
Love, et al., “Transgenic Birds by DNA Microinjection”, Bio/Technology, Jan. 1994, vol. 12, No. 1, pp. 60-63.
Slack, J.M.W., “Growth Control: Action Mouse”, Current Biology, Aug. 1, 1997, vol. 7, No. 8, pp. R467-R469.
International Search Report, PCT/US99/02511, Mailed May 13, 1999, 2 pages.
Berk et al., “Mice Lacking theskiProto-Oncogene Have Defects in Neurulation, Craniofacial Patterning, and Skeletal Development,”Genes&Development11:2029-2039 (1997).
Böttinger et al., “The Recombinant Proregion of Transforming Growth Factor β1 (Latency-Associated Peptide) Inhibits Active Transforming Growth Factor β1 in Transgenic Mice,”Proc. Natl. Acad. Sci93:5877-5882 (1996).
Gamer et al., “A Novel BMP Expressed in Developing Mouse Limb, Spinal Cord, and Tail Bud Is a Potent Mesoderm Inducer inXenopusEmbryos,”Developmental Biology208: 222-232 (1999).
Gentry and Nash, “The Pro Domain of Pre-Pro-Transforming Growth Factor β1 When Independently Expressed is a Functional Binding Protein for the Mature Growth Factor,”Biochemistry29:6851-6857 (1990).
Gonzalez-Cadavid et al., “Organization of the Luman Myostatin Gene and Expression in Healthy Men and HIV-Infected Men with Muscle Wasting,”Proc.Natl.Acad.Sci.95:14938-14943 (1998).
Lee and McPherron, “Myostatin and the Control of Skeletal Muscle Mass,”Curr. Opin. Gent. Dev.9:604-607 (1999).
Luo et al., “The Ski Oncoprotein Interacts with the Smad Proteins to Repress TGFβ Signaling,”Genes&Dev.13:2196-2206 (1999).
McPherron et al., “Regulation of Anterior/Posterior Patterning of the Axial Skeleton by Growth/Differentiation Factor 11,”Nature Genetics22:260-264 (1999).
Miyazono et al., “Latent High Molecular Weight Complex of Transforming Growth Factor β1,”J. Bio. Chem.263 (13):6407-6415 (1988).
Munger et al., “Latent Transforming Growth Factor-β: Structural Features and Mechanisms of Activation,”Kidney Intl.51:1376-1382 (1997).
Nakamura et al., “Activin-Binding Protein from Rat Ovary is Follistatin,”Science247:836-838 (1990).
Oh and Li, “The Signaling Pathway Mediated by the Type IIB Activin Receptor Controls Axial Patterning and Lateral Asymmetry in the Mouse,”Genes&Dev.11:1812-1826 (1997).
Sutrave et al., “Ski can Cause Selective Growth of Skeletal Muscle in Transgenic Mice,”Genes&Dev.4:1462-1472 (1990).
Constam and Robertson, “Regulation of Bone Morphogenetic Protein Activity by Pro Domains and Proprotein Convertases,” J. Cell. Biol., vol. 144, No. 1, Jan. 1999, pp. 139-149.

Affiliated with

Also associated with

Rating

Polynucleotides encoding promyostatin polypeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleotides encoding promyostatin polypeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotides encoding promyostatin polypeptides will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2774877