Vaccine compositions and methods of modulating immune responses

Details Vaccine compositions and methods of modulating immune responses Vaccine compositions and methods of modulating immune responses

2008-05-13

2008-05-13

Saunders, David A. (Department: 1644)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Fusion protein or fusion polypeptide

C514S04400A

Reexamination Certificate

active

07371387

ABSTRACT:
The invention provides compositions and methods for modulating immune responses in subjects. The invention is based, at least in part, on the discovery that an in-frame translation fusion of an antigen with an APC binding domain of an opsonin forms a molecule, that is, a fusion polypeptide, which when administered to a subject modulates an immune response to the antigen.

REFERENCES:
patent: 5891432 (1999-04-01), Hoo
patent: 6277368 (2001-08-01), Hiserodt et al.
patent: 6632436 (2003-10-01), Segal
patent: 2002/0076392 (2002-06-01), Hoo
Arvieux, et al. (1988). “Antigen-bound C3b and C4b Enhance Antigen-Presenting Cell Function in Activation of Human T-Cell Clones,”Immunology65:229-235.
Baier, et al. (1995). “Immunogenic Targeting of Recombinant Peptide Vaccines to Human Atigen-Presenting Cells by Chimeric Anti-HLA-DR and Anti-Surface Immunoglobulin D Antibody Fab Fragments In Vitro,”Journal of Virology69:2357-2365.
Berg, et al. (1994). “Comparing Macrophages and Dendritic Lwukocytes as Antigen-Presenting Cells for Humoral Responses In Vivo by Antigen Targeting,”Eur J Immunol24:1262-1268.
Carayanniotis, et al. (1987). “Adjuvant-Free IgG Responses Induced with Antigen Coupled to Antibodies Against Class II MHC,”Nature327:59-61.
Chu, et al. (1993). “Receptor-Mediated Antigen Delivery into Macrophages,”Journal of Immunology150:48-58.
Chu, et al. (1994). “Adjuvant-Free In Vivo Targeting,”Journal of Immunology1538-1545.
Dempsey, et al. (1996). “C3d of Complement as a Molecular Adjubant: Bridging Innate and Acquired Immunity,”Science271:348-350.
Estrada, et al. (1995). “Intestinal Immunization of Mice with Antigen Conjugated to Anti-MHC Class II Antibodies,”Vaccine13(10):901-907.
Gossselin, et al. (1992). “Enhanced Antigen Presentation Using Human Fcγ Receptor (Monocyte/Macrophage)-Specific Immunogens,”Journal of Immunology149(11):3477-3481.
Jacquier-Sarlin, et al. (1995). “Modulation of Antigen Processing and Presentation by Covalently Linked Complement C3b Fragment,”Immunology84:164-170.
Liu, et al. (1992). “FCγ RI-Targeted Fusion Proteins Result in Efficient Presentation by Human Monocytes of Antigenic and Antagonis T Cell Epitopes,”J. Clin. Invest.98(9):2001-2007.
Snider, et al. (1989). “Efficiency of Antigen Presentation Ater Antigen Targeting to Surface IgD, IgM, MHC, FcγRII and B220 Molecules on Murine Splenic B Cells,”Journal of Immunology143:59-65.
Squire, et al. (1994). “Antigen Presentation is Enhanced by Targeting Antigen to the FcεRII by Antigen-Anti-FcεRII Conjugates,”Journal of Immunology4388-4396.

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