Method of evaluating the catalytic activity of a rare earth...

Chemistry: analytical and immunological testing – Testing of catalyst

Reexamination Certificate

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C436S161000, C436S183000

Reexamination Certificate

active

07371578

ABSTRACT:
This invention provides a method of evaluating the catalytic activity of a rare earth alkoxide used as a starting material of a basic catalyst or an asymmetric synthesis catalyst. The rare earth alkoxide used as the subject of evaluation and 2,2′-dihydroxy-1, 1′-binaphthol are used as the starting material to prepare a rare earth complex catalyst which is then used to conduct the asymmetric epoxidation of an enone. The epoxy enone formed by this reaction, the unreacted enone, and the enantiomeric excess are measured, and from these results, the catalytic activity of the rare earth alkoxide is evaluated.

REFERENCES:
patent: 6201123 (2001-03-01), Daikai et al.
patent: 10-120668 (1998-05-01), None
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Nemoto, T. et al, Journal of the American Chemical Society 2001, 123, 2725-2732.
Chen, R. et al, Tetrahedron Letters 2001, 42, 6919-6921.
Nemoto, T. et al, Journal of the American Chemical Society 2001, 123, 9474-9475.
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Sugihara, H. et al, Tetrahedron Letters 2002, 43, 2735-2739.
Daikai, K. et al, Kidorui 1998, 32, 298-299.
Inanaga, J., Kidorui 1999, 34, 190-191.
Chen, R.-F. et al, Chinese Journal of Chemistry 2001, 19, 1225-1231.

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