Method of using estrogen-related receptor gamma (ERRγ)...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

Reexamination Certificate

active

07354713

ABSTRACT:
The present invention provides that ERRγ is both a breast cancer biomarker and a breast cancer treatment target. A high ERRγ level in breast cancer cells indicates good prognosis. A high level of ERRγ in breast tissue suspected of being cancerous is indicative of breast cancer. Analyzing ERRγ status and optionally along with the status of ERα can help breast cancer patients make treatment choices. Furthermore, breast cancer can be treated by decreasing ERRγ activity in breast cancer cells.

REFERENCES:
patent: 5298429 (1994-03-01), Evans et al.
Greenbaum et al., Genome Biology, 2003, vol. 4 (9), pp. 117.1-117.8.
Alberts et al. Molecular Biology of the Cell, 3rd Edition, 1994, p. 465.
Mallampalli et al., Biochem. J. 1996, vol. 38, pp. 333-341.
Fu et al., EMBO journal, 1996, vol. 15, pp. 4392-4401.
Giguère, Trends Endo. & Meta., Jul. 2002, 13(5): 220-225.
Chen, F., Zhang, Q., McDonald, T., Davidoff, M. J., Bailey, W., Bai, C., Liu, Q., and Caskey, C. T. Identification of two hERR2-related novel nuclear receptors utilizing bioinformatics and inverse PCR. Gene, 228: 101-109, 1999.
Coward, P., Lee, D., Hull, M. V., and Lehmann, J. M. 4-Hydroxytamoxifen binds to and deactivates the estrogen-related receptor gamma, Proc Natl Acad Sci U S A, 98: 8880-8884, 2001.
Eudy, J. D., Yao, S., Weston, M. D., Ma-Edmonds, M., Talmadge, C. B., Cheng, J. J., Kimberling, W. J., and Sumegi, J. Isolation of a gene encoding a novel member of the nuclear receptor superfamily from the critical region of Usher syndrome type lia at 1q41. Genomics, 50: 382-384, 1998.
Greschik, H., Wurtz, J. M., Sanglier, S., Bourguet, W., van Dorsselaer, A., Moras, D., and Renaud, J. P. Structural and functional evidence for ligand-independent transcriptional activation by the estrogen-related receptor 3. Mol Cell, 9: 303-313, 2002.
Heard, D. J., Norby, P. L., Holloway, J., and Vissing, H. Human ERRgamma, a third member of the estrogen receptor-related receptor (ERR) subfamily of orphan nuclear receptors: tissue-specific isoforms are expressed during development and in the adult. Mol Endocrinol, 14: 382-392, 2000.
Lu, D., Kiriyama, Y., Lee, K. Y., and Giguere, V. Transcriptional regulation of the estrogen-inducible pS2 breast cancer marker gene by the ERR family of orphan nuclear receptors. Cancer Res. 61: 6755-6761, 2001.
Tremblay, G. B., Bergeron, D., and Giguere, V. 4-Hydroxytamoxifen is an isoform-specific inhibitor of orphan estrogen-receptor-related (ERR) nuclear receptors beta and gamma. Endocrinology, 142: 4572-4575, 2001.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of using estrogen-related receptor gamma (ERRγ)... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of using estrogen-related receptor gamma (ERRγ)..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of using estrogen-related receptor gamma (ERRγ)... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2762706

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.