Stable lipid-comprising drug delivery complexes and methods...

Details Stable lipid-comprising drug delivery complexes and methods... Stable lipid-comprising drug delivery complexes and methods...

2008-04-22

2008-04-22

Schnizer, Richard (Department: 1635)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C435S458000, C424S450000, C536S023100, C530S350000

Reexamination Certificate

active

07361640

ABSTRACT:
Novel stable, concentrated, biologically active and ready-to-use lipid-comprising drug delivery complexes and methods for their production are described. The biological activity of the complexes produced are comparable to the formulations prepared according to the prior art admixture method and upon purification, the complexes produced by the method of this invention are 50 to 500 fold more concentrated than the complexes formed by admixture. The method described herein provides for the large scale production of lipid-comprising drug delivery systems useful for gene therapy and other applications.

REFERENCES:
patent: 4244946 (1981-01-01), Rivier et al.
patent: 4305872 (1981-12-01), Johnston et al.
patent: 4316891 (1982-02-01), Guillemin et al.
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4897355 (1990-01-01), Eppstein et al.
patent: 4958013 (1990-09-01), Letsinger
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5043164 (1991-08-01), Huang et al.
patent: 5059591 (1991-10-01), Janoff et al.
patent: 5100662 (1992-03-01), Bolcsak et al.
patent: 5196510 (1993-03-01), Rodwell et al.
patent: 5264618 (1993-11-01), Felgner et al.
patent: 5279833 (1994-01-01), Rose
patent: 5283185 (1994-02-01), Epand et al.
patent: 5286634 (1994-02-01), Stadler et al.
patent: 5334761 (1994-08-01), Gebeyehu et al.
patent: 5342921 (1994-08-01), Cousens et al.
patent: 5366737 (1994-11-01), Eppstein et al.
patent: 5374548 (1994-12-01), Caras
patent: 5459127 (1995-10-01), Felgner et al.
patent: 5491074 (1996-02-01), Aldwin et al.
patent: 5521291 (1996-05-01), Curiel et al.
patent: 5523222 (1996-06-01), Page et al.
patent: 5540933 (1996-07-01), Ruoslahti et al.
patent: 5545412 (1996-08-01), Eppstein et al.
patent: 5547932 (1996-08-01), Curiel et al.
patent: 5554382 (1996-09-01), Castor
patent: 5578475 (1996-11-01), Jessee
patent: 5627159 (1997-05-01), Shih et al.
patent: 5635487 (1997-06-01), Wolff et al.
patent: 5641662 (1997-06-01), Debs et al.
patent: 5650096 (1997-07-01), Harris et al.
patent: 5651964 (1997-07-01), Hung et al.
patent: 5661025 (1997-08-01), Szoka, Jr. et al.
patent: 5670347 (1997-09-01), Gopal
patent: 5672662 (1997-09-01), Harris et al.
patent: 5674908 (1997-10-01), Haces et al.
patent: 5674977 (1997-10-01), Gariepy et al.
patent: 5676954 (1997-10-01), Brigham
patent: 5705187 (1998-01-01), Unger
patent: 5705385 (1998-01-01), Bally et al.
patent: 5719131 (1998-02-01), Harris et al.
patent: 5736392 (1998-04-01), Hawley-Nelson et al.
patent: 5744335 (1998-04-01), Wolff et al.
patent: 5753262 (1998-05-01), Wyse et al.
patent: 5756264 (1998-05-01), Schwartz et al.
patent: 5756353 (1998-05-01), Debs
patent: 5776486 (1998-07-01), Castor et al.
patent: 5789245 (1998-08-01), Dubensky, Jr. et al.
patent: 5795587 (1998-08-01), Gao et al.
patent: 5807746 (1998-09-01), Lin et al.
patent: 5811297 (1998-09-01), Gopal
patent: 5824784 (1998-10-01), Kinstler et al.
patent: 5827703 (1998-10-01), Debs et al.
patent: 5834439 (1998-11-01), Haces et al.
patent: 5837533 (1998-11-01), Boutin
patent: 5844107 (1998-12-01), Hanson et al.
patent: 5869606 (1999-02-01), Whittaker
patent: 5877302 (1999-03-01), Hanson et al.
patent: 5885613 (1999-03-01), Holland et al.
patent: 5891468 (1999-04-01), Martin et al.
patent: 5906922 (1999-05-01), Whittaker et al.
patent: 5908635 (1999-06-01), Thierry
patent: 5908777 (1999-06-01), Lee et al.
patent: 5922859 (1999-07-01), Birnstiel et al.
patent: 5928944 (1999-07-01), Seth et al.
patent: 5939401 (1999-08-01), Marshall et al.
patent: 5948767 (1999-09-01), Scheule et al.
patent: 5955365 (1999-09-01), Skoza et al.
patent: 5972900 (1999-10-01), Ferkol, Jr. et al.
patent: 5972901 (1999-10-01), Ferkol, Jr. et al.
patent: 5976567 (1999-11-01), Wheeler et al.
patent: 5981501 (1999-11-01), Wheeler et al.
patent: 5994109 (1999-11-01), Woo et al.
patent: 5994316 (1999-11-01), Lollo et al.
patent: 6008202 (1999-12-01), Huang et al.
patent: 6008336 (1999-12-01), Hanson et al.
patent: 6011020 (2000-01-01), Gold et al.
patent: 6020202 (2000-02-01), Jessee
patent: 6037176 (2000-03-01), Bennett et al.
patent: 6043390 (2000-03-01), Nantz et al.
patent: 6051429 (2000-04-01), Hawley-Nelson et al.
patent: 6056973 (2000-05-01), Allen et al.
patent: 6071533 (2000-06-01), Papahadjopoulos et al.
patent: 6075012 (2000-06-01), Gebeyehu et al.
patent: 6077835 (2000-06-01), Hanson et al.
patent: 6086913 (2000-07-01), Tam et al.
patent: 6110916 (2000-08-01), Haces et al.
patent: 6147204 (2000-11-01), Gold et al.
patent: 6177554 (2001-01-01), Woo et al.
patent: 6224903 (2001-05-01), Martin et al.
patent: 6271208 (2001-08-01), Bischoff
patent: 6271209 (2001-08-01), Smith
patent: 6376248 (2002-04-01), Hawley-Nelson et al.
patent: 6399663 (2002-06-01), Haces et al.
patent: 6534484 (2003-03-01), Wheeler et al.
patent: 6586410 (2003-07-01), Wheeler et al.
patent: 6716882 (2004-04-01), Haces et al.
patent: 6773920 (2004-08-01), Dalby et al.
patent: 6835395 (2004-12-01), Semple et al.
patent: 6858224 (2005-02-01), Wheeler et al.
patent: 6890554 (2005-05-01), Jesse et al.
patent: RE039220 (2006-08-01), Gopal
patent: RE39220 (2006-08-01), Gopal
patent: 2001/0007666 (2001-07-01), Hoffman et al.
patent: 2001/0038851 (2001-11-01), Allen et al.
patent: 2002/0077305 (2002-06-01), Jesse et al.
patent: 2002/0086849 (2002-07-01), Gebeyehu et al.
patent: 2002/0192651 (2002-12-01), Wheeler et al.
patent: 2003/0144230 (2003-07-01), Hawley-Nelson et al.
patent: 2003/0203865 (2003-10-01), Harvie et al.
patent: 2004/0102606 (2004-06-01), Balicki et al.
patent: 2004/0152770 (2004-08-01), Haces et al.
patent: 2005/0025821 (2005-02-01), Harvie et al.
patent: 2005/0152964 (2005-07-01), Huang et al.
patent: 2006/0229246 (2006-10-01), Hawley-Nelson et al.
patent: 0 387 647 (1990-03-01), None
patent: 0 544 292 (1992-11-01), None
patent: 0 703 778 (1996-04-01), None
patent: 06-080560 (1994-03-01), None
patent: 10-505320 (1998-05-01), None
patent: WO 87/02061 (1987-04-01), None
patent: WO 91/04753 (1991-04-01), None
patent: WO 91/09958 (1991-07-01), None
patent: WO 93/03709 (1993-03-01), None
patent: WO 93/05162 (1993-03-01), None
patent: WO 93/18759 (1993-09-01), None
patent: WO 93/18852 (1993-09-01), None
patent: WO-93/19768 (1993-10-01), None
patent: WO 94/17832 (1994-08-01), None
patent: WO 94/23751 (1994-10-01), None
patent: WO 95/02397 (1995-01-01), None
patent: WO 95/12384 (1995-05-01), None
patent: WO 95/25809 (1995-09-01), None
patent: WO-95/32706 (1995-12-01), None
patent: WO 96/20208 (1996-07-01), None
patent: WO 96/22765 (1996-08-01), None
patent: WO 97/04748 (1997-02-01), None
patent: WO 97/11682 (1997-04-01), None
patent: WO-97/28817 (1997-08-01), None
patent: WO 98/00110 (1998-01-01), None
patent: WO 98/42383 (1998-10-01), None
patent: WO 99/34831 (1999-07-01), None
patent: WO-99/58694 (1999-11-01), None
patent: WO 00/03694 (2000-01-01), None
patent: WO 01/27154 (2001-04-01), None
patent: WO 02/088318 (2002-11-01), None
Mack et al (Am. J. Med. Sci. 307(2): 138-143, Feb. 1994).
1992 Sigma Chemical Company catalog, p. 1745.
Trubetskoy et al. (Biochim. et Biophys. Acta 1131: 311-313, 1992a).
Voet et al (IN Biochemistry, Second Edition, John Wiley and Sons Inc., 1995), p. 59.
Trubetskoy et al (Bioconj. Chem. 3: 323-327, 1992b.
HBS recipe retrieved from http://www-ufk.med.uni-rostock.de/main/hmueller/lablinks/recipes/hbshepes.htm on Oct. 14, 2004.
Roitt et al (In Immunology, Second Edition, J.B. Lippincott Co. 1989), p. 5.2.
Moir et al (J. Mol. Evol. 27 (1): 8-16 (1988).
Wu et al (J. Biol. Chem. 263(29): 14621-14624, 1988).
Torchilin et al (FASEB J. 6(9): 2716-2719, 1992.
Anderson (1996). “Human Gene Therapy,”Nature392: 25-30.
Behr et al. (Sep. 1989). “Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA.”Proc. Natl. Acad. Sci. USA86:6982-6986.
Bottega et al. (1992). “Inhibition of protein kinase C by cationic amphiphiles,”Biochem.31:9025-9030 (XP000645334).
Cheetham et al. (1990). “Cholesterol sulfate inhibits the fusion of sendai virus to biological and model membranes,”J. Biol. Chem.256:12404-12409.
Crystal. (1995). “

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