Process for preparation of valsartan

Details Process for preparation of valsartan Process for preparation of valsartan

2008-04-22

2008-04-22

Shameem, Golam M. M. (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S250000, C548S252000

Reexamination Certificate

active

07361770

ABSTRACT:
Valsartan of formula (I) is prepared by hydrolysis of valsartan benzyl ester with an alkali metal hydroxide, washing with an organic solvent, acidifying with hydrochloric acid and isolating valsartan from the reaction mixture

REFERENCES:
patent: 5399578 (1995-03-01), Buhlmayer et al.
patent: 5965592 (1999-10-01), Buhlmayer et al.
patent: WO 2004/111018 (2004-12-01), None
PCT International Search Report Dated Mar. 10, 2004.
Chemical Abstract No. 137:109453 (Zhongguo Yiyano Gongye Zazhi, 2001, 32(9), 385-387.
Chemical Abstract No. 138:89813 (CN 1317485).
Bio organic & Medicinal Chemistry Letters, vol. 4, No. 1, 29-34 (1994).

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