Anti-ulcer 5-(2-substituted ethenyl)-3-(2H)-furanones

Details Anti-ulcer 5-(2-substituted ethenyl)-3-(2H)-furanones Anti-ulcer 5-(2-substituted ethenyl)-3-(2H)-furanones

1989-12-12

1990-10-30

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514255, 514336, 514422, 514443, 514444, 514473, 546174, 546283, 544405, 549 58, 549 60, 549320, 548517, A61K 3144, A61K 3147, C07D21512, C07D40506

Patent

active

049669052

ABSTRACT:
A compound of the formula: ##STR1## in which R is alkyl, phenyl or halophenyl; R.sup.2 is substituted phenyl having from 1 to 3 substituents selected from halo, alkyl, alkylthio, alkylsulfonyl, cyano, trifluoromethyl, or R.sup.2 is pyridinyl, pyrazinyl, quinolinyl, N-alkylpyrrolyl, thienyl, benzothienyl, or furyl; and n is 1 or 2, are cytoprotective anti-ulcer agents.

REFERENCES:
Takashi et al. Chem. Abstracts. vol. 108, No. 13;112103R (1988).
Tsuge et al. Chem. Abstracts. vol. 107, No. 19;175802T (1987).
Ito et al. Chem. Abstracts. vol. 96, No. 17;142535j(1982).
Tsuge et al., Chem. Letters, 323, (1987).

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