Pyrrole derivatives, their preparation and their use as pharmace

Details Pyrrole derivatives, their preparation and their use as pharmace Pyrrole derivatives, their preparation and their use as pharmace

1989-05-23

1990-10-30

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514422, 514423, 514427, 514424, 514426, 548518, 548519, 548531, 548532, 548533, 548534, 548537, 548539, 548540, 548541, 548535, 548556, 548557, 548558, 548561, 540524, C07D207335, C07D28106, A61K 3145, A61K 3155

Patent

active

049669010

ABSTRACT:
Pyrrole derivatives of the general formula I ##STR1## wherein R denotes alkyl which is substituted by --NH.sub.2 or acylamino, R.sup.1 and R.sup.2 independently of one another denote hydrogen or alkyl having 1 to 4 carbon atoms, R.sup.3 denotes hydrogen, alkyl having 1 to 4 carbon atoms or a carboxylic acid grouping, R.sup.4 denotes a carboxylic acid grouping, nitro, alkylsulphinyl having 1 to 4 carbon atoms, optionally substituted phenylsulphinyl, alkylsulphonyl having 1 to 4 carbon atoms, optionally substituted phenylsulphonyl, alkylcarbonyl having 1 to 6 carbon atoms in the alkyl part, trifluoromethylcarbonyl, optionally substituted phenylcarbonyl, dicyanomethylene, formylvinyl, alkoxycarbonylvinyl having 1 to 6 carbon atoms in the alkoxy part or a carbonyl group, which is substituted by an optionally substituted aliphatic or aromatic 5- to 7-membered heterocyclic radical having 1 or 2 hetero atoms from the series comprising N, O and S, and pharmaceutically acceptable salts or acid addition salts thereof which are useful pharmacological active compounds. The invention also relates to methods for preparing the present compounds. The invention also includes formulations containing effective amounts of such compounds, and methods for administering same to patients for the treatment of diseases caused by restriction in cerebral function and/or for the treatment of cerebral aging processes.

REFERENCES:
patent: 2805227 (1957-09-01), Cosulich
patent: 3337562 (1967-08-01), Pesson et al.
patent: 4837225 (1989-06-01), Zoller et al.

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