Methods and compositions for the detection of familial hyperchol

Details Methods and compositions for the detection of familial hyperchol Methods and compositions for the detection of familial hyperchol

1986-10-30

1990-10-30

Yarbrough, Amelia Burgess

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 91, 435803, 436501, 436811, 530808, 530825, 935 9, 935 19, 935 77, 935 78, 935 86, 536 27, C12Q 168, C12P 1934, C12N 1500, G01N 33566

Patent

active

049668374

ABSTRACT:
Recombinant DNA transfer vectors containing DNA inserts which are complementary to either the human LDL receptor gene, or its mRNA transcript, are disclosed. Also disclosed are methods which utilize these genetic probes for diagnosing Familial Hypercholesterolemia (FH) in a suspected individual. A case study of numerous such individual are disclosed wherein the genetic deletion mutation is detailed with great precision through the practice of this invention.

REFERENCES:
patent: 4358535 (1982-11-01), Falkow et al.
patent: 4395486 (1983-07-01), Wilson et al.
patent: 4745060 (1988-05-01), Brown et al.
Horsthemke, B. et al., Hum. Genet. 71:75-78 (1985).
Chem. Abst. 106, No. 3, Issued Jan. 19, 1987, p. 494, 100449d Humphries, S. E. et al., "DNA Deletions. . . Diagnosis".
Humphries, S. E. et al., Verh. Dtsch. Ges. Inn. Med. 92:397-401 (1986).
Wieringa et al., (1981) Nucl. Acids Res., 9:489-501.
Goldstein et al., (1982) Medical Clinics of North America, 66:335-362.
Schneider et al., (1982) Jrnl. Biol. Chem. 257:2664-2673.
Tolleshaug et al. (1982) Cell, 30:715:724.
Schneider et al. (1983) Mol. Biol. Med., 1:353-367.
Tolleshaug et al. (1983) Cell, 32:941-951.
Russel et al., (1983) Proc. Natl. Acad. Sci, U.S.A., 80:7501-7505.
Russell et al., (1984) Cell, 37:577-585.
Yamamoto et al., (1984) Cell, 39:27-28.
Lehrman et al. (1985) Science, 227:140-146.
Sudhof et al. (1985), Science, 228:815-822.
Sauls et al. (1985), Clin. Chem., 31:804-811.
Lehrman et al., (1985), Cell, 41:735-743.
International Search Report for International Application No. PCT/US 85/02461, Apr. 24, 1986.
Yamamoto et al. (1986), Science, 232:1230-1237.
Lehrman et al. (1986), Proc. Natl. Acad. Sci. U.S.A., 83:3679-3683.
Kingsley et al. (1986), Jrnl. Cell Biol., 102:1576-1585.
Kingsley et al. (1986), Cell, 44:749-759.

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