Use of tumor susceptibilty gene 101 (TSG 101) as a...

Details Use of tumor susceptibilty gene 101 (TSG 101) as a... Use of tumor susceptibilty gene 101 (TSG 101) as a...

2011-03-01

2011-03-01

Yu, Misook (Department: 1643)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S007100

Reexamination Certificate

active

07897340

ABSTRACT:
The present invention discloses the link between oncogenic Ras and TSG101 and the negative effect of TSG101 on the expression of p21 in ovarian cancer. The present also discloses the use of TSG101 as a prognostic, diagnostic marker and a potential therapeutic target in cancer, especially ovarian cancer.

REFERENCES:
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patent: 6962779 (2005-11-01), Macina
patent: 2006/0193848 (2006-08-01), Cohen et al.
Lin, Chen, and Chang. Multiple truncated transcripts of TSG101 in gastrointestinal cancers. Journal of Gastroenterology and Hepatology, 1998. vol. 13, pp. 1111-1114.
Perkins, Slater, Sanders, and Prichard. Serum tumor markers. American Family Physician, 2003. vol. 68, pp. 1075-1082.
Erbagci, Yilmaz, and Kutlar. Menstrual cycle dependent variability for serum tumor markers CEA, AFP, CA 19-9, CA125 and CA15-3 in healthy women. Disease Markers, 1999. vol. 15, pp. 259-267.
National Cancer Institute. Digestive/Gastrointestinal Cancers. www.cancer.gov/cancertopics/cancersbybodylocation/ Aug. 24, 2009.
TSG101 gene information, http://www.ihop-net.org/UniPub/iHOP/gs/92891.html as downloaded Apr. 5, 2010. 2 pages.
Liu, Huang, You, Chou, Hu, Chao, Chen, and Cheng. Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas. Oncogene, 2002. vol. 21, pp. 4830-4837.

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