Selective N-acylation of A82846 glygopeptides analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

Reexamination Certificate

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Reexamination Certificate

active

07365053

ABSTRACT:
The present invention provides a process for selectively acylating an A82846A, A82846B, A82846C or PA-42867-A glycopeptide at the N1, N2 or N3 positions and the monoacylated compounds prepared therefrom.

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Cooper et al.,J. Antiobiotics, 49:6, 575-581 (1996) Reductive Alkylation of Glycopeptide Antibiotics: Synthesis and Antibacterial Activity.
Nagarajan et al.,J. Antibiotics, 41:10, 1430-1438 (1988) Synthesis and antibacterial activity of N-acyl vancomycins.
International Search Report PCT/US 01/04540, dtd. Oct. 24, 2001.

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