Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues
Reexamination Certificate
2011-04-12
2011-04-12
Navarro, Mark (Department: 1645)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
C424S184100, C424S185100
Reexamination Certificate
active
07923535
ABSTRACT:
A method is disclosed for producing a polypeptide with a modified activity or stability, by replacing an arginine residue capable of being ADP-ribosylated with a tryptophan or a phenylalanine. In one embodiment, compositions are provided that include polypeptides, such as alpha defensin, with arginine-to-tryptophan or arginine-to-phenylalanine substitutions, where the arginine residue is capable of being ADP-ribosylated. In another embodiment, methods are disclosed for modifying an immune response in a subject.
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Thiele et al., &#
Bortell Rita
Bourgeois Christelle
Moss Joel
Stevens Linda
Klarquist Sparkman LLP.
Navarro Mark
The United States of America as represented by the Secretary of
University of Massachusetts
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