Thrombin peptide derivative dimers

Details Thrombin peptide derivative dimers Thrombin peptide derivative dimers

2011-04-05

2011-04-05

Carlson, Karen Cochrane (Department: 1656)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S300000

Reexamination Certificate

active

07919457

ABSTRACT:
Disclosed are thrombin peptide derivative dimers comprising two polypeptides having the amino acid sequence Arg-Gly-Asp-Ala-Cys-Glu-Gly-Asp-Ser-Gly-Gly-Pro-Phe-Val (SEQ ID NO:2), or a C-terminal truncated fragment of the polypeptide having at least six amino acids. Zero, one, two, or three amino acids in the polypeptide or polypeptide fragment differ from the corresponding position of SEQ ID NO:2. Also disclosed are methods of treating a subject in need of treatment with a thrombin receptor agonist. The methods comprise the step of administering an effective amount of the thrombin peptide derivative described above.

REFERENCES:
patent: 5500412 (1996-03-01), Carney et al.
patent: 6855687 (2005-02-01), Carney et al.
patent: 6861407 (2005-03-01), Carney
patent: 6894027 (2005-05-01), Carney et al.
patent: 2004/0209819 (2004-10-01), Carney
patent: 2005/0203017 (2005-09-01), Hobson et al.
patent: WO 98/03632 (1998-01-01), None
Norfleet, A., et al., “Thrombin Peptide TP508 Accelerates Closure of Dermal Excisions in Animal Tissue with Surgically Induced Ischemia,”Wound Repair and Regeneration, 8(6): 517-529 (Nov.-Dec. 2000).
Norfleet, A., et al., “Thrombin Peptide, TP508, Stimulates Angiogenic Responses in Animal Models of Dermal Wound Healing, in Chick Chorioallantoic Membranes, and in Cultured Human Aortic and Microvascular Endothelial Cells,”General Pharmacology, 35: 249-254 (Nov. 2002).
Sower, L., et al., “Thrombin Peptide, TP508, Induces Differential Gene Expression in Fibroblasts Through a Nonproteolytic Activation Pathway,”Experimental Cell Research, 247: 422-431 (Mar. 1999).

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