Polyethylene glycol substituted phenyl glyoxals

Details Polyethylene glycol substituted phenyl glyoxals Polyethylene glycol substituted phenyl glyoxals

1989-05-05

1992-03-03

Moezie, F. T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

530402, 530406, C07C 4976

Patent

active

050935313

ABSTRACT:
A polyethylene glycol derivative of the formula ##STR1## wherein R represents a lower alkyl and n represents an optional positive integer which renders the average molecular weight of the polyethylene glycol moiety about 1,000 to 12,000, a peptide modified by said polyethylene glycol derivative and a method for production thereof.
The polyethylene glycol derivative (I) is capable of modifying the guanidino groups in peptides. The peptides modified by the polyethylene glycol derivative (I) are extremely stable, are considerably delayed in biological clearance (i.e. the durability is extended) and exhibit their physiological activities effectively over the long period.

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