Electricity: measuring and testing – Magnetic – With means to create magnetic field to test material
Patent
1998-04-06
2000-12-19
Noland, Thomas P.
Electricity: measuring and testing
Magnetic
With means to create magnetic field to test material
73866, 324236, G01N 3315, G01N 2774
Patent
active
061631493
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
The invention relates to a device for determining the dissolution time of medicaments in pressed form, such as tablets, pills, or capsules, wherein the device comprises a frame with a center column and a base plate, wherein the base plate comprises a plurality of holes, wherein the holes are covered from below by a mesh, and wherein test tubes are arranged upright in the holes within the frame, wherein a disk is movably inserted into each test tube for weighting the individual medication, according to the preamble of claim 1.
STATE OF THE ART
The measurement of the dissolution time of medication in pressed form, such as tablets and capsules, is performed in a standardized testing set-up in order to assure the reproduceability of the measurement results (in particular to DAB 10, 3rd Supplement 1994 or European Pharmacopoeia or USP [USA]). It is determined based on the dissolution testing whether the tablets or capsules dissolve in a liquid medium within the prescribed time under precisely set-forth conditions. The main part of the apparatus comprises a rigid frame which contains six cylindrical test tubes made of glass. Each tube is provided with a cylindrical disk made of a transparent plastic material of a precisely specified relative density and size. The test tubes are supported in their upright position by an upper and a lower transparent plate made of plastic, wherein the plate comprises in each case six boreholes. All boreholes have the same distance from the center point and the same distance from one another. A mesh made of a stainless steel wire is disposed at the underside of the lower plate. A metal column is disposed such at the center of the plate that the apparatus can be suspended from the metal column in a suspension arrangement and can be uniformly moved upward and downward by 50 to 60 mm with a motor 28 to 32 times per minute. For this purpose, the apparatus is suspended in a suitable container comprising the prescribed liquid. After filling one tablet or capsule into each tube and weighting the tube with the disk, the determination of the dissolution time of the tablets or capsules is performed by observation of the measurement device and time-keeping by the operating person.
A dissolution device for test bodies, in particular tablets, is known from the German printed patent document DE 35 20 034 C1, wherein the test bodies are disposed in containers of a dissolution basket between a Hall generator and a disk provided with a magnet. The containers of the dissolution basket are heated with a heating installation to a constant temperature. Once the test body dissolves, the disk moves together with the magnet toward the Hall generator such that the Hall generator emits a signal, wherein the signal can be fed to and displayed on a recording device upon exceeding of a sound threshold. The transmission of the energy for the electrical circuits in the dissolution basket occurs through contacts or with a high-frequency transmitter arid a high-frequency receiver. The transmission of the signals to the recording device is performed with optoelectronic components.
An automatic dissolution-time measurement device for the pharmaceutical quality control and production control of tablets and dragees or coated tablets in a conductive test liquid is known from the German printed patent document DE 94 19 245 U1, wherein the measurement device comprises a basket-like frame disposed in a beaker with a plurality of glass tubes disposed in the frame. The bases of the glass tubes are formed by circular sieve or mesh bottom plates as supporting bottom faces for the glass tubes. Each mesh bottom plate is comprised of two current-carrying, electrode-forming wire-mesh halves, wherein the wire-mesh halves are disposed at a spacing from one another thereby forming a slot in between. A test sample is disposed in each glass tube. The test sample is covered with a floating body or floater which rests on the test sample. The floater exhibits at its underside an embedded contact framework made of a me
REFERENCES:
patent: 3618395 (1971-11-01), Melliger
patent: 4754657 (1988-07-01), Schneider
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