Saccharide-measuring fluorescent monomer,...

Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...

Reexamination Certificate

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C562S007000

Reexamination Certificate

active

07873398

ABSTRACT:
A saccharide-measuring fluorescence sensor substance including a copolymer of at least the following two compounds (I) and (II) is provided:(I) a fluorescent monomer compound represented by the following formula (1): formula (1)wherein:Q, Q′ and D3may be the same or different, may be combined together into a fused ring, and are each a substituent selected from the group consisting of a hydrogen atom, a halogen atom, a hydroxyl group, and substituted or unsubstituted alkyl, acyl, oxyalkyl, carboxyl, carboxylate ester, carboxamido, cyano, nitro, amino and aminoalkyl groups; andD1, D2and D4each represent a substituent, wherein at least one of D1, D2and D4is a substituent group comprising a vinyl group at an end thereof, and wherein the substituent group comprising a vinyl group at an end thereof enables the fluorescent monomer compound to be soluble in water, and(II) at least one hydrophilic, polymerizable monomer having a vinyl group.

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Tony D. James et al, “Novel Saccharide-Photoinduced Electron Transfer Sensors Based on the Interaction of Boronic Acid and Amine”,J. Am. Chem. Soc., vol. 117, No. 35 (1995), American Chemical Society, pp. 8982-8987.
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