2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives,...

Details 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives,... 2-aryl-6-phenylimidazo[1,2-a]pyridine derivatives,...

2011-03-29

2011-03-29

Seaman, D. Margaret (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S121000

Reexamination Certificate

active

07915284

ABSTRACT:
The present invention is related to a compound of formula (I)wherein R1, R2, R3and R4are as defined herein, or an addition salt of an acid thereof, the pharmaceutical composition and preparation thereof, and the therapeutic use thereof in the treatment or the prevention of diseases involving Nurr-1 nuclear receptors, also known as NR4A2, NOT, TINUR, RNR-1 and HZF3.

REFERENCES:
patent: 2001035664 (2001-02-01), None
patent: WO 01/74813 (2001-10-01), None
patent: WO 2004/026867 (2004-04-01), None
patent: WO 2004/072050 (2004-08-01), None
patent: WO 2005/086808 (2005-09-01), None
Enguehard, C., et. al., (Hetero)Arylation of 6-Halogenoimidazo [1,2-a]Pyridines Differently Substituted at C(2): Influence of the 2-Substituent on the Suzuki Cross-Coupling Reaction, Helvetica Chimica Acta, vol. 84, (2001).
Wang, Z., et. al., Structute and Function of Nurr1 Identifies a Class of Ligand-Independent Nuclear Receptors, Nature vol. 423, 555-560, (2003).

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