Method for studying, determining or evaluating...

Details Method for studying, determining or evaluating... Method for studying, determining or evaluating...

2011-04-12

2011-04-12

Ulm, John D (Department: 1649)

Chemistry: analytical and immunological testing

Biological cellular material tested

C436S086000

Reexamination Certificate

active

07923254

ABSTRACT:
A method for studying, determining or evaluating a pharmacological action of a test substance, the method including subjecting the brain tissue of an SART stressed animal administered with the test substance to an expression proteome analysis, where expression changes of NSF (N-ethylmaleimide sensitive fusion protein), which is or is not modified after translation, in the SART stressed animal administered with the test substance as compared with an SART stressed animal to which a test substance is not administered is used as an index.

REFERENCES:
patent: 2006/0051376 (2006-03-01), Nishioka
patent: 2006/0263388 (2006-11-01), Nishioka
patent: 2007/0218037 (2007-09-01), Nishioka
patent: 2008/0194038 (2008-08-01), Nishioka et al.
patent: WO 2004/039383 (2004-05-01), None
patent: WO 2006/095674 (2006-09-01), None
Hata et al., “Changes in CNS Levels of Serotonin and Its Metabolite in SART-Stressed (Repeatedly Cold-Stressed) Rats”, Japan J. Pharmacol., vol. 56, pp. 101-104, 1991.
Soeller et al., “Neurotransmission: Harnessing Fusion Machinery at the Synapse”, Trends Neurosci., vol. 17, No. 8, pp. 344-348, 1994.
Ishida, “Proteomics Ni Okeru Tanpakushitsu Hatsugen Differential Kaiseki—Keiko Hyoshiki Nijigen Difference Denki Eido: Ettan™ DIGE”, Clinical Testing, vol. 47, No. 11, pp. 1269-1276, 2003, (Untranslated Japanese Document).
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Hata et al., “Plasma Catecholamine Levels in SART-Stressed Rats and Effects of Drugs on Stress-Induced Alteration in Plasma and Brain Catecholamine Levels”, J. Auton. Pharmacol., vol. 11, pp. 15-25, 1991.

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