Method for controlling the therapy of patients suffering...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Reexamination Certificate

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C436S518000

Reexamination Certificate

active

07915002

ABSTRACT:
Disclosed is a method for controlling the therapeutic treatment of a patient suffering from cardiac insufficiency. In said method, it is determined how the concentration of at least one of the vasoactive peptides adrenomedullin (ADM), endothelin-1(ET-1), and/or vasopressin (AVP) changes in the patient's blood after beginning the therapy, and the therapeutic measures are considered to be unsatisfactory and are modified in case said concentration does not decrease at all or not enough in relation to a threshold value for the respective vasoactive peptide.

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Written Opinion of the International Search Authority for corresponding PCT/EP2007/006393.
Joachim Struck et al., “Proteolytic processing pattern of the endothelin-1 precursor in vivo”, Peptides 26 (2005) 2482-2486.
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Jana Papassotiriou et al., “Immunoluminometric Assay for Measurement of the C-Terminal Endothelin-I Precursor Fragment in Human Plasma”, Clinical Chemistry 52:6, (2006), 1144-1151.
Nils G. Morgenthaler et al., “Assay for the Measurement of Copeptin, a Stable Peptide Derived from the Precursor of Vasopressin”, Clinical Chemistry 52:1, (2006), 112-119.
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