3-arylthioindole-2-carboxamide derivatives and analogs...

Details 3-arylthioindole-2-carboxamide derivatives and analogs... 3-arylthioindole-2-carboxamide derivatives and analogs...

2011-08-30

2011-08-30

Padmanabhan, Sreeni (Department: 1627)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S414000, C548S469000

Reexamination Certificate

active

08008340

ABSTRACT:
A method for inhibiting casein kinase Iε activity, comprising administering to said patient a therapeutically effective amount of a compound of formula I.its stereoisomer, enantiomer, racemate, tautomer or pharmaceutically acceptable salt thereof.

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Boschelli et al. “Inhibition of E-Selectin-,ICAM-1, and VCAM-1-Mediated Cell Adhesion by Benzo[b]thiphene, Benzofuran-, Indole-, and Naphthalene-2-carboxamides: Identification of PD 144795 as an Antiinflammatory Agent” J. Med. Chem., 1995, vol. 38, pp. 4597-4614.
Hasegawa, M., et. al.,, Regulation of the Circadian Oscillator inXenopusRetinal Photoreceptors by Protein Kinases Sensitive to the Stress-Activatived Protein Kinase Inhibitor, SB203580, The Journal of Biological Chemistry, vol. 279, No. 21 pp. 22738-22746 (2004).

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