Sustained-release, oral pharmaceutical forms of formulation

Details Sustained-release, oral pharmaceutical forms of formulation Sustained-release, oral pharmaceutical forms of formulation

2011-03-15

2011-03-15

Fubara, Blessing M (Department: 1613)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

C424S457000, C514S649000

Reexamination Certificate

active

07906141

ABSTRACT:
A sustained-release, oral pharmaceutical formulation of tramadol comprising a compound formed in situ of tramadol or its salt and a pharmaceutically acceptable acidic substance. The compound formed in situ has a desired water solubility. Also provided are methods of treatment using the pharmaceutical formulations. Method for preparing such formulations are also provided. The preparation method comprises repeatedly mixing tramadol or its salt with the acidic substance, and moistening the mixture and formulating the mixture under an energy input, such as heat or pressure. Optionally, drying, repeated granulating, extrudation and pelleting may also be included.

REFERENCES:
patent: 5516803 (1996-05-01), Raffa
patent: 5776492 (1998-07-01), Betzing et al.
patent: 5914129 (1999-06-01), Mauskop
patent: 5958452 (1999-09-01), Oshlack et al.
patent: 19927688 (2000-12-01), None
patent: 0546676 (1993-06-01), None
Remington's Pharmaceutical Sciences, (Alfonso R. Gennaro, edited), p. 1641-1647 (1990).
Remington's Pharmaceutical Sciences, (Alfonso R. Gennaro, edited), pp. 1641-1647 (1990).

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