Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2011-01-11
2011-01-11
Davis, Zinna N (Department: 1625)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S307000, C544S128000, C546S144000
Reexamination Certificate
active
07868003
ABSTRACT:
The invention relates to substituted 4-phenyltetrahydroisoquinolines of formula Iwherein R1-R8, N, W, X and Z are defined herein. These compounds and pharmaceutical compositions comprising them are useful in the treatment of respiratory disorders, sleep apnea, kidney disorders, high blood pressure, hypertension, disorders of the central nervous system and the like.
REFERENCES:
patent: 0825178 (1998-02-01), None
patent: WO 01/21582 (2001-03-01), None
patent: WO 01/32624 (2001-05-01), None
patent: WO 01/44164 (2001-06-01), None
patent: WO 01/72742 (2001-10-01), None
patent: WO 01/79186 (2001-10-01), None
patent: WO 03/048129 (2003-06-01), None
patent: WO 03/055880 (2003-07-01), None
patent: WO 2004/085404 (2004-10-01), None
Akhter, S., et. al., Squalamine, a Novel Cationic Steroid, Specifically Inhibits the Brush-border Na+/H+ Exchanger Isoform NHE3, The American Physiological Society, 1999, c136-c144.
Ben-Ishai, D., et. al., Intra VS. Intermolecular Amidoalkylation of Aromatics, Tetrahedron vol. 43, No. 2, pp. 439-450 (1987).
Cuevas, et. al., alpha′-Silylated Tertiary Benzamides as Dual Ortho-and alpha′-Carbanion Synthons. , Tetrahedron Letters; 30;43;1989; pp. 5837-5840.
Fliegel, L., et. al., Regulation and Characterization of the Na+/H+ Exchanger, Biochem. Cell. Biol., 76: (1998), 735-741.
Johnson, P.D., et. al., Synthesis of N-Substituted 1,2,5-Thiadiazolidine and 1,2,6-Thiadiazinane 1,1-dioxides from Primary Amines, Tetrahedron Letters vol. 44, (2003), pp. 5483-5485.
Kano, S., et. al., A Synthesis of Simple 4,4-Disubstituted Tetrahydroisoquinolines by Cyclization of Alpha, Alpha-Disubstituted Phenylacetamides, Chem. Pham. Bull. 33(1) 340-346 (1985).
Klapars, A., et. al. , A General and Efficient Coppert Catalyst for the Amidation of Aryl Halides, J. Am. Chem. Soc. vol. 124, (2002) pp. 7421-7428.
Klapars, A., et. al., A General and Efficient Copper Catalyst for the Amidation of Aryl Halides and the N-Arylation of Nitrogen Heterocycles, J. Am. Chem. Soc., (2001) pp. 7727-7729 vol. 123.
Ma, E., et. al., Expression and Localization of Na+/H+ Exchangers in Rat Central Nervous System, Neuroscience vol. 79, No. 2, pp. 591-603 (1997).
Mederski, W. W. K. R., et. al., A Convenient Synthesis of 4-Aminoaryl Substituted Cyclic Imides , Tetrahedron Letters vol. 44, (2003) pp. 2133-2136.
Wang, J., et. al., Aminolysis of Esters or Lactones Promoted by NaHMDS-A General and Effecient Method for the Preparation of N-Aryl Amides, Synlett (2001) No. 9, pp. 1485-1487.
Zhao, X., et. al., A Practical Synthesis of 4-(3′,4′-Dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline, OPPI Briefs; 27;4;1995; pp. 513-516.
Heinelt Uwe
Hofmeister Armin
Lang Hans-Jochen
Licher Thomas
Wirth Klaus
Davis Zinna N
Lin Jiang
Sanofi-Aventis
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