Composite material useful as biomaterial and its preparation

Details Composite material useful as biomaterial and its preparation Composite material useful as biomaterial and its preparation

2011-08-23

2011-08-23

Gupta, Anish (Department: 1654)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

C530S324000, C530S325000, C530S326000, C530S327000, C530S328000, C530S356000

Reexamination Certificate

active

08003611

ABSTRACT:
The present invention aims at providing a biomaterial composite not having risks of pathogen infection and unfavorable side effects such as rejection response. According to the invention, there is provided a biomaterial composite, which comprises a polypeptide and a calcium phosphate compound, said peptide comprising the units of Formulas (I) to (III):in-line-formulae description="In-line Formulae" end="lead"?[—(OC—(CH2)m—CO)p-(Pro-Y-Gly)n-]a  (I)in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?[—(OC—(CH2)m—CO)q-(z)r-]b  (II)in-line-formulae description="In-line Formulae" end="tail"?in-line-formulae description="In-line Formulae" end="lead"?[—HN—R—NH—]c  (III)in-line-formulae description="In-line Formulae" end="tail"?wherein m, p, q, Y, n, Z, r, R, a, b and c are as defined in the specification. The composite of the invention is particularly suitable for an artificial bone due to its high biocompatibility, high endurance and mechanical strength. Further, the invention can provide a process of the composite according to the invention can for preparation of the composite having excellent mechanical characteristics by a simple procedure.

REFERENCES:
Tanihara et al. JP2005-58499. Publication date Mar. 10, 2005. Machine assisted English translation.
L. L. Hench et al., An Introduction to Bioceramics, pp. 1-24, World Scientific, NY, 1993.
L.L. Hench et al., “Bonding Mechanism at the Interface of Ceramics Prosthetic Materials”, Journal of Biomedical Materials Research, vol. 2, (Part 1), pp. 117-141, 1971.
M. Jarcho et al., “Tissue, Cellular and Subcellular Events at a Bone-Ceramic Hydroxylapatite Interface”, Journal of Bioengineering, vol. 1, pp. 79-92, 1977.
M. Neo et al., “Apatite Formation on Three Kinds of Bioactive Material at an Early stage in vivo: A Comparative Study by Transmission Electron Microscopy”, Journal of Biomedical Materials Research, vol. 27, pp. 999-1006, 1993.

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