Tricyclic benzopyrane compound

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C548S151000

Reexamination Certificate

active

07964623

ABSTRACT:
This invention relates to benzopyran derivatives of formula (I) or (II), or pharmaceutically acceptable salts thereofwherein R1and R2are independently of each other hydrogen atom, C1-6alkyl group or C6-14aryl group, R3is hydrogen atom or C1-6alkylcarbonyloxy group, or together with R4forms a bond, R4is hydrogen atom, or together with R3forms a bond, m is an integer of 0 to 4, n is an integer of 0 to 4, V is a single bond, CR7R8, NR9, O, S, SO or SO2, R5is hydrogen atom or C1-6alkyl group, R6is hydrogen atom, C1-6alkyl group, C3-8cycloalkyl group, C3-8cycloalkenyl group, amino group, C1-6alkylamino group, di-C1-6alkylamino group, C6-14arylamino group, C2-9heteroarylamino group, C6-14aryl group, C2-9heteroaryl group or C2-9heterocyclyl group, A is 5-, 6- or 7-member ring fused with benzene ring, as constituent atom of the ring, oxygen atom, nitrogen atom or sulfur atom may be contained in the number of 1 to 3 alone or in a combination thereof, the number of unsaturated bond in the ring is 1, 2 or 3 including an unsaturated bond of the benzene ring to be fused, carbon atoms constituting the ring may be carbonyl or thiocarbonyl. These compounds are useful as an anti-arrhythmic agent.

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Chan, Wai N. et al. “Conformational Preference of the 6-acetyl Group in Novel Anticonvulsanttrans4s-benzamido-benzo[b]pyran-3r-ols;”Bioorganic&Medicinal Chemistry Letters, vol. 7, No. 12, pp. 1573-1576, 1997.

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