Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Reexamination Certificate
2011-04-12
2011-04-12
Kemmerer, Elizabeth C. (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
C514S001100, C514S002300, C514S007600, C514S008100, C514S008200, C514S008500, C514S008800, C514S008900, C514S009100, C514S011800, C514S012200, C514S017200, C514S020600, C514S020900, C424S085500, C424S130100, C424S422000, C424S423000, C424S425000, C424S428000
Reexamination Certificate
active
07923432
ABSTRACT:
The present invention relates to the design and composition of a depot implant for optimal delivery of growth factors to treat bone avascular necrosis, in that such depot implant is constructed to be in a cylinder (rod) or sphere shape and have a natural or synthetic polymer scaffold with or without impregnated calcium phosphate particles. The density of the depot is higher than a typical BMP sponge carrier to facilitate its implantation and slower release of the growth factor. The scaffold is such that it has adequate porosity and pore size to facilitate growth factor seeding and diffusion throughout the whole of the bone structure resulting in increased new blood vessel growth and density in the avascular necrotic bone. In addition, the shape of the depot implant allows for delivery through a cannula or large bore needle.
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Kemmerer Elizabeth C.
Warsaw Orthopedic Inc.
Xie Xiaozhen
LandOfFree
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