Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Reexamination Certificate
2011-03-08
2011-03-08
Monshipouri, Maryam (Department: 1656)
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
C424S001730, C424S501000
Reexamination Certificate
active
07901666
ABSTRACT:
The invention discloses a pharmaceutical composition for treating a subject comprising two or more bioactive nanoparticles, thus treating the subject by co-administering the bioactive nanoparticles to the subject, wherein a first and a second bioactive nanoparticles comprise a shell portion that is dominated by positively charged chitosan, a core portion that contains negatively charged substrate, and at least a first bioactive agent in the first nanoparticle and a second bioactive agent in the second nanoparticle.
REFERENCES:
patent: 6383478 (2002-05-01), Prokop et al.
patent: 6649192 (2003-11-01), Alonso Fernandez et al.
patent: 6726934 (2004-04-01), Prokop
patent: 2006/0051423 (2006-03-01), Heppe et al.
Lin YH et al. “Preparation and characterization of nanoparticles shelled with chitosan for oral insulin delivery” Biomacromolecules 2007;8:146-152.
Lin YH et al. “Novel nanoparticles for oral insulin delivery via the paracellular pathway” Nanotechnology 2007;18:1-11.
van der Lubben IM et al. “Chitosan and its derivatives in mucosal drug and vaccine delivery” Euro J Pharma Sci 2001;14:201-207.
Hosny EA et al. “Oral delivery of insulin from enteric-coated capsules containing sodium salicylate” Int J Pharmaceutics 2002;237:71-76.
Thanou M et al. “Chitosan and its derivatives as intestinal absorption enhancers” Adv. Drug Deliv. Rev. 2001;50:S91-S101.
Smith J et al. “Effect of chitosan on epithelial cell tight junctions” Pharmaceutical Research 2004;21:43-49.
Lin YH et al. “Preparation of nanoparticles composed of chitosan/poly-gamma-glutaraldehyde and evaluation of their permeability through Caco-2 cells” Biomacromolecules 2005;6:1104-1112.
Fernandez-Urrusuno R et al. “Enhancement of nasal absorption of insulin using chitosan nanoparticles” Pharmaceutical Research 1999;16:1576-1581.
Mi FL et al. “Oral delivery of peptide drugs using nanoparticles self-assembled by poly(r-glutamic acid) and a chitosan derivative functionalized by trimethylation” Bioconjugate Chem 2008;19:1248-1255.
Sung Hsing-Wen
Tu Hosheng
GP Medical, Inc.
Monshipouri Maryam
National Tsing Hua University
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