Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-li

Details Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-li Indenyl hydroxamic acids and hydroxy ureas as inhibitors of 5-li

1990-01-16

1992-03-03

Evans, Joseph E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514471, 514575, 549 77, 549496, 562621, 562622, 562623, C07C25904, A61K 3119, C07D33322, C07D30702

Patent

active

050933566

ABSTRACT:
Compounds having the formula I: ##STR1## are inhibitors of the 5-lipoxygenase enzyme. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.

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