Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-04-26
2011-04-26
Weddington, Kevin (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S325000
Reexamination Certificate
active
07932268
ABSTRACT:
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the MTP inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.
REFERENCES:
patent: 3983140 (1976-09-01), Endo et al.
patent: 4231938 (1980-11-01), Monaghan et al.
patent: 4346227 (1982-08-01), Terahara et al.
patent: 4448784 (1984-05-01), Glamkowski et al.
patent: 4450171 (1984-05-01), Hoffman et al.
patent: 4499289 (1985-02-01), Baran et al.
patent: 4613610 (1986-09-01), Wareing
patent: 4647576 (1987-03-01), Hoefle et al.
patent: 4686237 (1987-08-01), Anderson
patent: 4716175 (1987-12-01), Hoefle et al.
patent: 4871721 (1989-10-01), Biller
patent: 4924024 (1990-05-01), Biller
patent: 5015644 (1991-05-01), Roth et al.
patent: 5026554 (1991-06-01), Bartizal et al.
patent: 5117080 (1992-05-01), Lee
patent: 5510379 (1996-04-01), Lee et al.
patent: 5595872 (1997-01-01), Wetterau, II et al.
patent: 5684014 (1997-11-01), Muller et al.
patent: 5712279 (1998-01-01), Biller et al.
patent: 5712396 (1998-01-01), Magnin et al.
patent: 5739135 (1998-04-01), Biller et al.
patent: 5760246 (1998-06-01), Biller et al.
patent: 5767115 (1998-06-01), Rosenblum et al.
patent: 5786361 (1998-07-01), Muller et al.
patent: 5789197 (1998-08-01), Wetterau, II et al.
patent: 5811429 (1998-09-01), Connell et al.
patent: 5827875 (1998-10-01), Dickson, Jr. et al.
patent: 5883109 (1999-03-01), Gregg et al.
patent: 5885983 (1999-03-01), Biller et al.
patent: 5952498 (1999-09-01), Lenfers et al.
patent: 5990110 (1999-11-01), Firestone
patent: 6034115 (2000-03-01), Connell et al.
patent: 6057339 (2000-05-01), Gregg
patent: 6066650 (2000-05-01), Biller et al.
patent: 6066653 (2000-05-01), Gregg et al.
patent: 6114341 (2000-09-01), Muller et al.
patent: 6121283 (2000-09-01), Chang et al.
patent: 6140343 (2000-10-01), DeNinno et al.
patent: 6194454 (2001-02-01), Dow
patent: 6245775 (2001-06-01), Muller et al.
patent: 6265431 (2001-07-01), Muller et al.
patent: 6297233 (2001-10-01), Stein et al.
patent: 6344450 (2002-02-01), Bisacchi et al.
patent: 6479503 (2002-11-01), Muller et al.
patent: 6492365 (2002-12-01), Wetterau, II et al.
patent: 6498156 (2002-12-01), Glombik et al.
patent: 6620821 (2003-09-01), Robl
patent: 6627636 (2003-09-01), Robl
patent: 6720351 (2004-04-01), Bertinato et al.
patent: 6774236 (2004-08-01), Lenfers et al.
patent: 6812345 (2004-11-01), Robl et al.
patent: 6846836 (2005-01-01), Hamann et al.
patent: 6858622 (2005-02-01), Muller et al.
patent: 6875782 (2005-04-01), Cheng et al.
patent: 6884812 (2005-04-01), Glombick et al.
patent: 6916809 (2005-07-01), Chen et al.
patent: 6916813 (2005-07-01), Atwal et al.
patent: 6949572 (2005-09-01), Bertinato et al.
patent: 6979692 (2005-12-01), Bertinato et al.
patent: 7053080 (2006-05-01), Davis et al.
patent: 7056906 (2006-06-01), Strony
patent: 7358254 (2008-04-01), Robl et al.
patent: 7394501 (2008-07-01), Iwata et al.
patent: 7645732 (2010-01-01), Ye et al.
patent: 2002/0035064 (2002-03-01), Robl et al.
patent: 2002/0045271 (2002-04-01), Hussain et al.
patent: 2003/0069221 (2003-04-01), Kosoglou et al.
patent: 2003/0109543 (2003-06-01), Ogletree
patent: 2003/0153541 (2003-08-01), Dudley et al.
patent: 2003/0162788 (2003-08-01), Thomas et al.
patent: 2003/0187053 (2003-10-01), Bertinato et al.
patent: 2004/0014748 (2004-01-01), Grutzmann et al.
patent: 2004/0058908 (2004-03-01), Keller et al.
patent: 2005/0075367 (2005-04-01), Hagiwara et al.
patent: 2005/0090426 (2005-04-01), Blumberg
patent: 2005/0101561 (2005-05-01), Tunac
patent: 2006/0069161 (2006-03-01), Lee et al.
patent: 2006/0135460 (2006-06-01), Widder et al.
patent: 2006/0153913 (2006-07-01), Yamane et al.
patent: 2006/0160834 (2006-07-01), Fong et al.
patent: 2006/0166999 (2006-07-01), Grutzmann et al.
patent: 2006/0205726 (2006-09-01), Hagiwara et al.
patent: 2006/0211020 (2006-09-01), Farrer et al.
patent: 2006/0211762 (2006-09-01), Rongen et al.
patent: 2006/0252733 (2006-11-01), Jansen
patent: 2006/0270655 (2006-11-01), Swick et al.
patent: 2007/0027093 (2007-02-01), Ogawa et al.
patent: 2007/0032404 (2007-02-01), Sweet et al.
patent: 2007/0088089 (2007-04-01), Wisler
patent: 2007/0093468 (2007-04-01), Wisler
patent: 2007/0093527 (2007-04-01), Wisler
patent: 2007/0098778 (2007-05-01), Borsadia
patent: 2007/0099884 (2007-05-01), Erondu et al.
patent: 2008/0016127 (2008-01-01), Field
patent: 2008/0033019 (2008-02-01), Stamler
patent: 2008/0051427 (2008-02-01), Schuckler
patent: 2008/0103122 (2008-05-01), Veltri
patent: 2008/0161279 (2008-07-01), Wisler
patent: 2008/0175864 (2008-07-01), Ye et al.
patent: 2008/0241869 (2008-10-01), Davis
patent: 2008/0248070 (2008-10-01), Tunac
patent: 2008/0253985 (2008-10-01), Wisler
patent: 2008/0255084 (2008-10-01), Webb
patent: 2008/0280992 (2008-11-01), Kunz et al.
patent: 2009/0042835 (2009-02-01), Davis
patent: 2009/0042941 (2009-02-01), Rader
patent: 2009/0054393 (2009-02-01), Wisler
patent: 2009/0093527 (2009-04-01), Li et al.
patent: 727895 (1998-07-01), None
patent: 2091102 (1993-09-01), None
patent: 2291471 (2000-06-01), None
patent: 2325201 (2001-05-01), None
patent: 19951022 (2001-04-01), None
patent: 0142146 (1985-05-01), None
patent: 0221025 (1987-05-01), None
patent: 0325130 (1989-07-01), None
patent: 0705831 (1996-04-01), None
patent: 0779276 (1997-06-01), None
patent: 0779279 (1997-06-01), None
patent: 0799828 (1997-10-01), None
patent: 0802198 (1997-10-01), None
patent: 1099442 (2001-05-01), None
patent: 1 181 954 (2002-02-01), None
patent: 2596393 (1987-10-01), None
patent: 2205837 (1988-12-01), None
patent: 2002-220345 (2002-08-01), None
patent: WO-86/03488 (1986-06-01), None
patent: WO-86/07054 (1986-12-01), None
patent: WO-96/26205 (1996-08-01), None
patent: WO-96/26948 (1996-09-01), None
patent: WO-96/40640 (1996-12-01), None
patent: WO-97/41111 (1997-11-01), None
patent: WO-98/03069 (1998-01-01), None
patent: WO-98/03174 (1998-01-01), None
patent: WO-98/23593 (1998-06-01), None
patent: WO-98/27979 (1998-07-01), None
patent: WO-98/31225 (1998-07-01), None
patent: WO-98/31366 (1998-07-01), None
patent: WO-98/31367 (1998-07-01), None
patent: WO-98/50028 (1998-11-01), None
patent: WO-00/38725 (2000-07-01), None
patent: WO-01/08679 (2001-02-01), None
patent: WO-2004/028544 (2004-04-01), None
patent: WO-2004/110368 (2004-12-01), None
patent: WO-2004/110375 (2004-12-01), None
patent: WO-2005/000217 (2005-01-01), None
patent: WO-2005/033100 (2005-04-01), None
patent: WO-2005/051382 (2005-06-01), None
patent: WO-2005/072740 (2005-08-01), None
patent: WO-2005/084666 (2005-09-01), None
patent: WO-2005/087234 (2005-09-01), None
patent: WO-2005/094864 (2005-10-01), None
patent: WO-2005/097131 (2005-10-01), None
patent: WO-2006/046623 (2006-05-01), None
patent: WO-2006/062748 (2006-06-01), None
patent: WO-2006/063128 (2006-06-01), None
patent: WO-2006/108666 (2006-10-01), None
patent: WO-2006/111238 (2006-10-01), None
patent: WO-2007/047724 (2007-04-01), None
patent: WO-2007/047880 (2007-04-01), None
patent: WO-2008/012056 (2008-01-01), None
patent: WO-2008/021353 (2008-02-01), None
patent: WO-2008/030382 (2008-03-01), None
patent: WO-2008/072061 (2008-06-01), None
patent: WO-2008/075949 (2008-06-01), None
patent: WO-2008/079398 (2008-07-01), None
patent: WO-2008/090198 (2008-07-01), None
patent: WO-2008/115574 (2008-09-01), None
Catapano, Ezetimibe: a selective inhibitor of cholesterol absorption, European Heart Journal Supplements 2001 (3, Supplemental E): E6-E10).
Knopp RH, Drug treatment of lipid disorders. New England J. Med. 1999; 341(7): 498-511; electronic pp. 1-25.
Aggarwal, et al; BMC Cardiovasc. Disord. 27;5(1):30 (2005).
Chandler, et al., J. Lipid. Res. 44(10):1887-901 (2003).
Cuchel et al.,
Goodwin & Procter LLP
The Trustees of the University of Pennsylvania
Weddington Kevin
LandOfFree
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