Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Reexamination Certificate
2011-06-28
2011-06-28
Kemmerer, Elizabeth C. (Department: 1646)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
C514S013300, C514S019200, C514S019300, C435S183000, C435S375000
Reexamination Certificate
active
07968527
ABSTRACT:
Methods and compositions for inhibiting FGF signaling are described. Methods of the invention include contacting an FGF-responsive cell with exogenous heparan sulfate 6-O endosulfatase (Sulf1) in an amount effective to modify endogenous heparan sulfate, thereby inhibiting FGF signaling. Methods of the invention also include contacting an FGF-responsive cell with an exogenous Sulf1-modified compound, the exogenous Sulf1-modified compound being characterized by the ability to reduce binding of FGF2 or FGF4 to FGFR1. Compositions comprising exogenous Sulf1-modified compounds are also provided for use in conjunction with methods of the present invention.
REFERENCES:
patent: 7129072 (2006-10-01), Schlessinger et al.
patent: 2003/0147875 (2003-08-01), Rosen et al.
patent: WO 00/74634 (2000-12-01), None
patent: WO 03/012053 (2003-02-01), None
Esner et al., Int. J. Dev. Biol., 2002, 46:817-825.
Bellosta et al., Mol. Cell. Biol., 2001, 21(17):5946-5957.
Lai et al., J. Biol. Chem., 2003, 278(25):23107-23117.
Itoh et al., Dev., 1994, 120:2703-2711.
Lai et al., Gastroenterology, Jan. 2004, vol. 126(1):231-248. (see Abstract).
Morimoto-Tomita et al., J. Biol. Chem., 2002, vol. 277(51):49175-49185.
Jinping Lai et al, Loss of HSulf-1 Up-Regulates Heparin-binding Growth Factor Signalaing in Cancer, The Journal of Biological Chemistry, Jun. 20, 2003, vol. 278, No. 25, p. 23107-23117.
J. Lai, Loss of Hsulf-1 Up-regulates Heparin-binding Growth Factor Signaling in Cancer, J. Biol. Chem. 278(25): 23107-23117 (Jun. 2003).
J.P. Lai et al., hSulfl Sulfatase Promotes Apoptosis of Hepatocellular Cancer Cells by Decreasing Heparin-binding Growth Factor Signaling, Gastroenterology 126(1): 231-248 (Jan. 2004).
J. Morimoto-Tomita et al., Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans, J. Biol. Chem. 277(51): 49175-49185 (Dec. 2002).
X. Ai et al., Substrate Specificity and Domain Functions of Extracellular Heparan Sulfate 6-O-Endosulfatases, Qsulf1 and Qsulf2, J. Biol. Chem. 281(8): 4969-4976 (Feb. 2004).
K. Narita et al., Hfulf-1 Inhibits Angiogenesis and Tumorigenesis In vivo, Cancer Res. 66(12): 6025-6032 (Jun. 2006).
Ishibara, M., Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2, Glycobiology, vol. 4, No. 6 pp. 817-824, 1994.
Lai, et al., “hSulf1 Sulfatase Promotes Apoptosis of Hepatocellular Cancer Cells by Decreasing Heparin-Binding Growth Factor Signaling”, Gastroenterology 2004; 126:231-248.
Guimond, et al., “Activating and Inhibitory Heparin Sequences for FGF-2 (Basic FGF)”, Journal of Biological Chemistry, vol. 268, No. 32, Nov. 15, pp. 23906-23914,1993.
Askikari-Hada, et al., “Characterization of Growth Factor-binding Structures in Heparin/Heparan . . . ”, Journal of Biol.Chem., vol. 279, No. 13, Mar. 26, pp. 12346-12354, 2004.
Allen, et al., “Role of heparan sulfate as a tissue-specific regulator of FGF-4 and FGF receptor recognition”, Journal of Cell Biol., vol. 155, No. 5, Nov. 26, 2001; 846-857.
Wu, et al., “The Involvement of Heparan Sulfate (HS) in FGF1/HS/FGFR1 Signaling Complex”, Journal of Biol. Chem., vol. 278, No. 19, May 9, pp. 17121-17129, 2003.
Wang, et al., “QSulf1, a heparan sulfate 6-0-endosulfatase, inhibits fibroblast growth factor signaling . . . ”, PNAS, Apr. 6, 2004, vol. 101, No. 14, 4833-4838.
Ai Xingbin
Emerson, Jr. Charles P.
Boston Biomedical Research Institute
Farrell Kevin M.
Kemmerer Elizabeth C.
Pierce Atwood LLP
Wilson David J.
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