Preparation of [4S-(4.alpha.,7.alpha.,10a.beta.)]-4-amino-octahy

Details Preparation of [4S-(4.alpha.,7.alpha.,10a.beta.)]-4-amino-octahy Preparation of [4S-(4.alpha.,7.alpha.,10a.beta.)]-4-amino-octahy

1999-07-08

2000-12-19

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540490, 560 25, 560169, C07D28102, C07C26100, C07C22904, C07C22922

Patent

active

061629138

ABSTRACT:
N-protected-L-homocysteine disulfide of the formula ##STR1## or an activated form thereof is reacted with (S)-2-amino-6,6-dimethoxyhexanoic acid, methyl ester to give the disulfide intermediate of the formula ##STR2## Cleavage of the disulfide bond followed by acid catalyzed cyclization produces the N-protected lactam of formula III which is useful for preparing the pharmaceutically active compound omapatrilat.

REFERENCES:
patent: 5508272 (1996-04-01), Robl
Umemoto et al., Bull. chem. Soc. Japan, vol. 59, p. 447-452 (1986).

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