Method for stimulating self-renewal of neural stem cells and...

Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S368000, C435S373000

Reexamination Certificate

active

07901936

ABSTRACT:
The present invention provides a mechanism for obtaining an almost unlimited source of stem cells. A method for the expansion of a population of stem cells that retain their developmental capacity comprises co-culture of a stem cell population with a trophic support, for example, endothelial cells or conditioned medium derived from endothelial cell culture. The method also provides a method for enhancing neurogenesis when neural stem cells are co-cultured with the endothelial cell-derived trophic support to retain their neurogenic potential.

REFERENCES:
patent: 6468794 (2002-10-01), Uchida et al.
patent: 6638763 (2003-10-01), Steindler et al.
patent: 2002/0098584 (2002-07-01), Palmer et al.
patent: 2003/0095956 (2003-05-01), Weiss et al.
patent: 2003/0166276 (2003-09-01), Carpenter
patent: 2005/0037488 (2005-02-01), Mitalipova et al.
Leventhal et al. 1999. Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependymal zone. MCN. 13:450-464 (IDS reference-DB).
Doetsch 2003. A niche for adult neural stem cells. Current Opinion in Genetics & Development. 13:543-550.
Kirschenbaum et al., “Brain-derived neurotrophic factor promotes the survival of neurons arising from the adult rat forebrain subependymal zone,” Proc. Natl. Acad. Sci. USA, 92, pp. 210-214 Jan. 1995.
Leventhal et al., “Endothelial Trophic Support of Neuronal Production and Recruitment from the Adult Mammalian Subependyma,” Molecular and Cellular Neuroscience, 13, pp. 450-464 (1999).
Pagano et al., “Isolation and Characterization of Neural Stem Cells from the Adult Human Olfactory Bulb,” Stem Cells, 18, pp. 295-300 (2000).
Palmer et al., “Vascular Niche for Adult Hippocampal Neurogenesis,” Journal of Comparative Neurology, 425, pp. 479-494 (2000).
Qian et al., “Timing of CNS Cell Generation: A Programmed Sequence of Neuron and Glial Cell Production from Isolated Murine Cortical Stem Cells,” Neuron, 28, pp. 69-80, Oct. 2000.
Takahashi et al., “Retinoic Acid and Neurotrophins Collaborate to Regulate Neurogenesis in Adult-Derived Neural Stem Cell Cultures,” J. Neurobiol. 38(1), pp. 65-81, 1999.
Palmer et al., “Fibroblast Growth Factor-2 Activates a Latent Neurogenic Program in Neural Stem Cells from Diverse Regions of the Adult CNS,” Journal of Neuroscience, 19(19), pp. 8487-8497 Oct. 1999.
Shimazaki et al., “The Ciliary Neurotrophic Factor/Leukemia Inhibitory Factor/gp130 Receptor Complex Operates in the Maintenance of Mammalian Forebrain Neural Stem Cells,” Journal of Neuroscience, 21(19), pp. 7642-7653, Oct. 2001.
Zhu et al., “Vascular endothelial growth factor promotes proliferation of cortical neuron precursors by regulating E2F expression,” The FASEB Journal, 17, pp. 186-193, Feb. 2003.
Tropepe et al., “Direct Neural Fate Specification from Embryonic Stem Cells: A Primitive Mammalian Neural Stem Cell Stage Acquired through a Default Mechanism,” Neuron, 30, pp. 65-78, Apr. 2001.
Hitoshi et al., “Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells,” Genes & Development, 16, pp. 846-858 (2002).
Nacher et al., “NMDA receptor antagonist treatment increases the production of new neurons in the aged rat hippocampus,” Neurobiology of Aging, 24, pp. 273-284 (2003).
Kempermann et al., “Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice,” Development, 130, pp. 391-399 (2003).
Aberg et al., “Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus,” Journal of Neuroscience, 20(8), pp. 2896-2903, Apr. 2000.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for stimulating self-renewal of neural stem cells and... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for stimulating self-renewal of neural stem cells and..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for stimulating self-renewal of neural stem cells and... will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2718059

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.