Method for detecting and removing endotoxin

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C435S007370

Reexamination Certificate

active

08003313

ABSTRACT:
The present invention relates to bacteriophage tail proteins and the derivatives and fragments thereof that are capable of binding endotoxins in the absence of bivalent positive ions, especially Ca2+or Mg2+. Further, the present invention relates to methods for depleting endotoxins from solutions and samples using the bacteriophage tail proteins according to the present invention and to a detection method for endotoxins.

REFERENCES:
patent: 5179018 (1993-01-01), Bogard, Jr. et al.
patent: 5506121 (1996-04-01), Skerra et al.
patent: 5510242 (1996-04-01), Blais et al.
patent: 5627266 (1997-05-01), Wainwright et al.
patent: 5747455 (1998-05-01), Wainwright et al.
patent: 5760177 (1998-06-01), Iwanaga et al.
patent: 5917022 (1999-06-01), Davies
patent: 5990301 (1999-11-01), Colpan et al.
patent: 6365147 (2002-04-01), Luo et al.
patent: 6376462 (2002-04-01), Gazzano-Santoro et al.
patent: 6384188 (2002-05-01), Hoess et al.
patent: 6942802 (2005-09-01), Sundberg et al.
patent: 7585620 (2009-09-01), Schutz et al.
patent: 2002/0130082 (2002-09-01), Todokoro et al.
patent: 2002/0147315 (2002-10-01), Pyo et al.
patent: 2004/0248298 (2004-12-01), Schutz et al.
patent: 10129815 (2003-01-01), None
patent: 10228133 (2004-01-01), None
patent: 10307793 (2004-09-01), None
patent: 0074240 (1983-03-01), None
patent: 0232754 (1992-07-01), None
patent: 0592989 (1994-04-01), None
patent: 2192633 (1988-01-01), None
patent: WO 94/14837 (1994-07-01), None
patent: WO 95/05393 (1995-02-01), None
patent: WO 95/08560 (1995-03-01), None
patent: WO 95/25117 (1995-09-01), None
patent: WO 99/15676 (1999-04-01), None
patent: WO 00/08463 (2000-02-01), None
patent: WO 01/27289 (2001-04-01), None
patent: WO 01/66718 (2001-09-01), None
patent: WO 02/083710 (2002-10-01), None
patent: WO 2004/001418 (2003-12-01), None
Database EMBL, “Gp12 short tail fiber,” Database accession No. AAQ17871, Jul. 2003.
Galanos and Luderitz, “Electrodialysis of lipopolysaccharides and their conversion to uniform salt forms,”Eur. J. Biochem., 54:603-610, 1975.
Hancock and Reeves, “Bacteriophage resistance inEscherichia coliK-12: general pattern of resistance,”J. Bacteriol., 121:983-993, 1975.
Hantke, “Major outer membrane proteins ofE. coliK12 serve as receptors for the phages T2 (protein Ia) and 434 (protein Ib),”Mol.Gen Genet., 164:131-135, 1978.
Leiman et al., “Structure and morphogenesis of bacteriophage T4m”Cell Mol. Life Sci., 60:2356-2370, 2003.
Merino et al., “Identification of the cell surface receptor for bacteriophage 18 fromAeromonas hydrophila,” Research in Microbiology, 141:173-180, 1990.
NCBI Databank, Databank Accession No. AAQ17871, dated Jul. 11, 2003.
NCBI Databank, Databank Accession No. AY266303, dated Jul. 11, 2003.
Petsch and Anspach, “Endotoxin removal from protein solutions,”J. Biotechnol., 76:97-119, 2000.
Riede et al., “DNA sequence heterogeneity in the genes of T-even typeEscherichia coliphages encoding the receptor recognizing protein of the long tail fibers,”Mol. Gen. Genet., 195:144-152, 1984.
Seckler, “Folding and function of repetitive structure in the homotrimeric phage P22 tailspike protein,”J. Struct. Biol., 122:216-222, 1998.
Triantafilou et al., “Lipopolysaccharide (LPS) labeled with Alexa 488 hydrazide as a novel probe for LPS binding studies,”Cytometry, 41:316-320, 2000.
Troelstra et al., “Dual effects of soluble CD14 on LPS priming of neutrophils,”J. Leukoc. Biol., 61:173-178, 1997.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method for detecting and removing endotoxin does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for detecting and removing endotoxin, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for detecting and removing endotoxin will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-2715441

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.